Evidence map›Paper›PMID 31194577›Full record

ArticleASN neuro

Small Interference RNA Targeting Connexin-43 Improves Motor Function and Limits Astrogliosis After Juvenile Traumatic Brain Injury.

Aleksandra Ichkova, Andrew M Fukuda, Nina Nishiyama, Germaine Paris, Andre Obenaus, Jerome Badaut

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Development of an HInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Role of astrocytes connexins - pannexins in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  5. Review
  6. The Potential Role of Connexins in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleksandra Ichkova1 CNRS UMR5287, University of Bordeaux, France.
Andrew M Fukuda2 Department of Physiology, Loma Linda University, CA, USA.
Nina Nishiyama3 Department of Pediatrics, Loma Linda University Medical Center, CA, USA.
Germaine Paris3 Department of Pediatrics, Loma Linda University Medical Center, CA, USA.
Andre Obenaus3 Department of Pediatrics, Loma Linda University Medical Center, CA, USA.ORCID 0000-0003-0081-6950
Jerome Badaut1 CNRS UMR5287, University of Bordeaux, France.ORCID 0000-0001-8475-0519

Funding

AQP4 and JNK Inhibition Together Reduce Edema and Excitotoxic Injury in jTBIR01HD061946 · NICHD · LOMA LINDA UNIVERSITY · PI ASHWAL, STEPHEN · 2009 to 2013
$1.7M
NICHD NIH HHS R01 HD061946
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Recovery of FunctionAnimalsBrain EdemaBrain Injuries, TraumaticConnexin 43GliosisMaleMotor ActivityRatsRats, Sprague-DawleyRNA, Small InterferingConnexin 43Gja1 protein, ratRNA, Small Interferingastrocyte networkblood–brain barrierdrug targetsgliovascular unittraumatic brain injury

Identifiers

PMID31194577
PMCPMC6566476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.