ReviewThe Journal of clinical endocrinology and metabolism2019
Effects of the Timing of Sex-Steroid Exposure in Adolescence on Adult Health Outcomes.
Review in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Growth retardation in long-term high-risk neuroblastoma survivors treated with high-dose chemotherapy: the impact of large vertebral irradiation and gonadal damage.Bone marrow transplantation · 2026Article
- Working memory and daily internalizing problems: Pubertal timing moderates adult relations.Journal of affective disorders · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Article
- Pubertal timing in adolescence and adulthood: Relations among contemporaneous and retrospective measures.Developmental psychology · 2025Article
- Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.BMC psychiatry · 2023Article
- Associations Between Reproductive Factors and the Risk of Adult-Onset Asthma: A Prospective Cohort Study of European Ancestry.Journal of general internal medicine · 2023Article
- Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Transition of young adults with metabolic bone diseases to adult care.Frontiers in endocrinology · 2023Review
- Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.The Journal of endocrinology · 2022Article
- Trend in age at menarche and its association with body weight, body mass index and non-communicable disease prevalence in Indonesia: evidence from the Indonesian Family Life Survey (IFLS).BMC public health · 2022Article
- Genetic conditions of short stature: A review of three classic examples.Frontiers in endocrinology · 2022Review
- Recent advancement in the treatment of boys and adolescents with hypogonadism.Therapeutic advances in endocrinology and metabolism · 2022Review
- Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study.Frontiers in genetics · 2022Article
- Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture.Nutrients · 2021Review
- [Analysis on the law of height growth spurt in adolescence of children and adolescents in Zhongshan City].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Exploring the Interaction Effects of Gender Contentedness and Pubertal Timing on Adolescent Longitudinal Psychological and Behavioral Health Outcomes.Frontiers in psychiatry · 2021Article
- Testosterone Use in Adolescent Males: Current Practice and Unmet Needs.Journal of the Endocrine Society · 2021Review
- PRACTICE VARIATION IN THE MANAGEMENT OF GIRLS AND BOYS WITH DELAYED PUBERTY.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2020Article
- Androgen Treatment in Adolescent Males With Hypogonadism.American journal of men's healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
contextVariation in pubertal timing is associated with a wide range of adult risks and outcomes, but it is unclear whether these associations are causal, and it is largely unknown whether these associations can be modified by treatment. EVIDENCE ACQUISITION: We conducted PubMed searches to identify Mendelian randomization (MR) studies on the influence of pubertal timing on adult health and studies on sex-steroid treatment of the following conditions associated with reduced reproductive endocrine function in adolescence: constitutional delay, Turner syndrome, and Klinefelter syndrome. EVIDENCE SYNTHESIS: Results of MR studies suggest that earlier pubertal timing increases body mass index; increases risk for breast, ovarian, endometrial, and prostate cancers; elevates fasting glucose levels and blood pressure; impairs lung capacity and increases risk for asthma; leads to earlier sexual intercourse and first birth; decreases time spent in education; and increases depressive symptoms in adolescence. Later pubertal timing appears to lower bone mineral density (BMD). Although studies of constitutional delay have not shown that sex-steroid treatment alters adult height or BMD, studies of girls with Turner syndrome and boys with Klinefelter syndrome suggest that earlier initiation of sex-steroid treatment improves physical and neurocognitive outcomes.
conclusionsDespite having some limitations, MR studies suggest that pubertal timing causally influences many adult conditions and disease risks. Studies of Turner syndrome and Klinefelter syndrome suggest that earlier sex-steroid exposure may have short- and long-term benefits. The mechanisms underlying these findings and the effects of trends and treatments affecting pubertal timing remain to be determined.
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