Evidence map›Paper›PMID 31194186›Full record

ReviewThe World Allergy Organization journal2019

The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions.

Adam Fox, J Andrew Bird, Alessandro Fiocchi, Jan Knol, Rosan Meyer, Seppo Salminen, Gong Sitang, Hania Szajewska, Nikolaos Papadopoulos

Abstract readReview
In one paragraph

Review in The World Allergy Organization journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Management of IgE-mediated food allergy in the 21st century.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. New Insights in Therapy for Food Allergy.Foods (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Food allergy and the microbiome: Current understandings and future directions.The Journal of allergy and clinical immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam FoxDept of Paediatric Allergy, Guy's & St Thomas' Hospitals NHS Foundation Trust, Westminster Bridge, London SE1 7EH, United Kingdom.
J Andrew BirdUniversity of Texas Southwestern Medical Center, Department of Pediatrics, Division of Allergy and Immunology, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USA.
Alessandro FiocchiAllergy Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.
Jan KnolWageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands.
Rosan MeyerImperial College, Dept Paediatrics, London, UK.
Seppo SalminenFunctional Foods Forum, Faculty of Medicine, Itäinen pitkäkatu 4A, 20014 Turku, Finland.
Gong SitangGuangzhou Women and Children's Medical Center, Tianhe, Guangzhou, 510620, China.
Hania SzajewskaDepartment of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, Zwiriki i Wigury 63A, Poland.
Nikolaos PapadopoulosProfessor of Allergy & Paediatric ​Allergy Division of Infection, Immunity & ​Respiratory Medicine, University of Manchester, 5th Floor (Research), Royal Manchester Childrens Hospital, Manchester M13 9WL, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cow's milk allergy is one of the most commonly reported childhood food allergies, with increasing incidence, persistence and severity in many countries across the world. The World Allergy Organization Special Committee on Food Allergy has identified cow's milk allergy as an area in need of a rationale-based approach in order to make progress against what it considered an onerous problem, with worldwide public health impact. There is growing interest in the potential role of the gut microbiota in the early programming and development of immune responses and allergy. This discussion paper considers the rationale and available evidence for modulation of the gut microbiota and for the use of synbiotics in the management of infants at risk of, or living with cow's milk allergy and summarizes remaining research questions that need to be answered for the development of evidence-based recommendations.

Indexed as

AllergyAnaphylaxisBifidobacteriaCow's milk allergyDysbiosisIgELactobacilliMicrobiotaPrebioticProbioticSynbioticWorld Allergy Organization

Identifiers

PMID31194186
PMCPMC6555906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.