Evidence map›Paper›PMID 31194171›Full record

ArticleKidney international reports2019

Diabetes Mellitus Modifies the Associations of Serum Magnesium Concentration With Arterial Calcification and Stiffness in Incident Hemodialysis Patients.

Wei Chen, Jessica Fitzpatrick, Jose M Monroy-Trujillo, Stephen M Sozio, Bernard G Jaar, Michelle M Estrella, Tong Tong Wu, Michal L Melamed, Rulan S Parekh, David A Bushinsky

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Magnesium to prevent kidney disease-associated vascular calcification: crystal clear?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Wei ChenDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Jessica FitzpatrickDepartment of Medicine and Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Jose M Monroy-TrujilloDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stephen M SozioDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bernard G JaarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michelle M EstrellaDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Tong Tong WuDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Michal L MelamedDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Rulan S ParekhDepartment of Medicine and Pediatrics, University of Toronto, Toronto, Ontario, Canada.
David A BushinskyDepartment of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Johns Hopkins Medicine · USUniversity of Rochester · USUniversity of Toronto · CAAlbert Einstein College of Medicine · USSan Francisco VA Medical Center · US

Funding

Hypercalciuria and Bone Quality in the Genetic Hypercalciuric Stone-Forming RatsR01DK075462 · NIDDK · UNIVERSITY OF ROCHESTER · PI BUSHINSKY, DAVID A · 2008 to 2019
$3.8M
Longitudinal Study of DialysisR01DK072367 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PAREKH, RULAN S · 2007 to 2011
$3.7M
Calcification Propensity, using Dynamic Light Scattering, to Study Vascular Calcification in Patients with Advanced Chronic Kidney DiseaseK23DK114476 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHEN, WEI · 2018 to 2021
$953k
Cardiovascular Disease in Children with Chronic Kidney DiseaseK24DK090070 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI MITSNEFES, MARK M. · 2011 to 2015
$839k
NIDDK NIH HHS K23 DK114476NIDDK NIH HHS K24 DK090070NIDDK NIH HHS R01 DK072367NIDDK NIH HHS R01 DK075462
6 · The paper itself

Abstract

introductionMagnesium (Mg) may protect against arterial calcification. We tested the hypotheses that a higher serum Mg concentration is associated with less arterial calcification and stiffness in patients on hemodialysis (HD) and that these associations are modified by diabetes mellitus.

methodsWe performed cross-sectional analyses of 367 incident HD patients from the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) cohort. Measures of arterial calcification and stiffness included coronary arterial calcification (CAC) and thoracic aortic calcification (TAC) scores, ankle brachial index (ABI; high ABI: >1.4 or incompressible vessels), pulse wave velocity (PWV), and pulse pressure.

resultsMean Mg was 1.8 ± 0.2 mEq/l and 58% had diabetes. Among nondiabetic individuals, per 0.1 mEq/l higher Mg, non-zero CAC score was lower (% difference: -15.4%; 95% confidence interval [CI]: -28% to -0.55%;

conclusionDiabetes modified the associations of serum Mg with arterial calcification and stiffness in incident HD patients. Higher Mg was associated with less arterial calcification and less peripheral arterial stiffness among nondiabetic individuals, but Mg was only associated with TAC among diabetic individuals with higher Mg being associated with higher likelihood of having TAC score >0.

Indexed as

arterial calcificationarterial stiffnessdiabetes mellitusmagnesiummineral metabolism

Identifiers

PMID31194171
PMCPMC6551514
OpenAlexW2921932199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.