ReviewNeurobiology of pain (Cambridge, Mass.)
A new aspect of chronic pain as a lifestyle-related disease.
Review in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Canadian Adaptation of REVEAL(OT) for Chronic Pain Management: Rapid Qualitative Analysis Results.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2026Article
- Pain characteristics and psychological factors that mediate the association between obesity and outcomes of interdisciplinary pain rehabilitation: a registry-based cohort study.Annals of medicine · 2025Article
- Comparison of Temporomandibular Disorder Signs and Symptoms in CrossFitInternational journal of environmental research and public health · 2025Article
- Eating habits and the desire to eat healthier among patients with chronic pain: a registry-based study.Scientific reports · 2024Article
- Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases.Journal of clinical medicine · 2024Review
- The Role of the Brain-Derived Neurotrophic Factor in Chronic Pain: Links to Central Sensitization and Neuroinflammation.Biomolecules · 2024Review
- Estimation of cognitive impairment in chronic pain patients and characteristics of estimated mild cognitive impairment.Frontiers in neurology · 2024Article
- Antinociceptive effect of intermittent fasting via the orexin pathway on formalin-induced acute pain in mice.Scientific reports · 2023Article
- EEG-based sensory testing reveals altered nociceptive processing in elite endurance athletes.Experimental brain research · 2023Article
- Article
- Machine Learning Identifies Chronic Low Back Pain Patients from an Instrumented Trunk Bending and Return Test.Sensors (Basel, Switzerland) · 2022Article
- Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from "Fear-Avoidance Belief".International journal of molecular sciences · 2022Review
- Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens.Molecular brain · 2022Article
- The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain.Advances in rheumatology (London, England) · 2021Article
- Serotonergic Neurotransmission System Modulator, Vortioxetine, and Dopaminergic DMolecules (Basel, Switzerland) · 2021Article
- Association of Temporomandibular Disorder Symptoms with Physical Fitness among Finnish Conscripts.International journal of environmental research and public health · 2021Article
- Cognitive Reserve as a Protective Factor of Mental Health in Middle-Aged Adults Affected by Chronic Pain.Frontiers in psychology · 2021Article
- Voluntary Forelimbs Exercise Reduces Immobilization-Induced Mechanical Hyperalgesia in the Rat Hind Paw.Pain research & management · 2021Article
- The Aftermath of COVID-19 Lockdown on Daily Life Activities in Orthopaedic Patients.Journal of pain research · 2021Article
- Comprehensive Analysis of Aerobic Exercise-Related Genes Identifies CDCA4 That Promotes the Progression of Osteosarcoma.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise has been established as a low-cost, safe, and effective way to manage chronic intractable pain. We investigated the underlying mechanisms of exercise-induced hypoalgesia (EIH) using a mouse model of neuropathic pain (NPP). Epigenetic changes in activated microglia and maintained GABA synthesis in the spinal dorsal horn may contribute to EIH. Voluntary exercise (VE), a strong reward for animals, also induced EIH, which may be due in part to the activation of dopamine (DA) neurons in the ventral tegmental area (VTA). VE increases the expression of pCREB in dopaminergic neurons in the VTA, which would enhance dopamine production, and thereby contributes to the activation of the mesolimbic reward system in NPP model mice. We demonstrated that neurons in the laterodorsal tegmental and pedunculopontine tegmental nuclei, a major input source of rewarding stimuli to the VTA, were activated by exercise. Chronic pain is at least partly attributed to sedentary and inactive lifestyle as indicated by the Fear-avoidance model. Therefore, chronic pain could be recognized as a lifestyle-related disease. Physical activity/inactivity may be determined by genetic/epigenetic and neural factors encoded in our brain. The hypothalamus and reward system is closely related in the axis of food intake, energy metabolism and physical activity. Understanding the interactions between the mesolimbic DA system and the hypothalamus that sense and regulate energy balance is thus of significant importance. For example, proopiomelanocortin neurons and melanocortin 4 receptors may play a role in connecting these two systems. Therefore, in a certain sense, chronic pain and obesity may share common behavioral and neural pathology, i.e. physical inactivity, as a result of inactivation of the mesolimbic DA system. Exercise and increasing physical activity in daily life may be important in treating and preventing chronic pain, a life-style related disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.