Evidence map›Paper›PMID 31194022›Full record

ArticleJournal of orthopaedic translation2019

Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement.

Xiao Lin, Jun Ge, Donglei Wei, Chun Liu, Lili Tan, Huilin Yang, Ke Yang, Huan Zhou, Bin Li, Zong-Ping Luo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiao LinOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Jun GeOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Donglei WeiOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Chun LiuOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Lili TanInstitute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China.
Huilin YangOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Ke YangInstitute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China.
Huan ZhouSchool of Mechanical Engineering, Jiangsu University of Technology, Changzhou, 213001, China.
Bin LiOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Zong-Ping LuoOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.
Lei YangOrthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis work focuses on tackling the inadequate bone/implant interface strength of acrylic bone cements, which is a formidable problem diminishing their clinical performance, especially in percutaneous kyphoplasty surgery.

methodsA new strategy of incorporating magnesium particles into clinically used poly(methylmethacrylate) (PMMA) bone cement to prepare a surface-degradable bone cement (SdBC) is proposed and validated both

resultsThis surface degradation characteristic enables osseointegrative, angiogenic and antiinfective properties. SdBC showed fast surface degradation and formed porous surfaces as designed, while the desirable high compressive strengths (≥70 MPa) of the cement were preserved. Besides, the SdBC with proper Mg content promoted osteoblast adhesion, spreading, proliferation and endothelial cell angiogenesis capacity compared with PMMA. Also, SdBC demonstrated clear inhibitory effect on

conclusionsThis work validates a new concept of designing bioactive bone/implant interface in PMMA bone cement. And this surface-degradable bone cement possesses great potential for minimally invasive orthopaedic surgeries such as percutaneous kyphoplasty. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: This work reports PMMA/Mg surface-degradable acrylic bone cements that possess enhanced osseointegrative, angiogenic and antiinfective properties that are lacking in the clinically used acrylic bone cements. This new kind of bone cements could improve the treatment outcome of many orthopaedic surgeries such as percutaneous kyphoplasty and arthroplasty.

Indexed as

AntiinfectionBone cementKyphoplastyMagnesiumOsseointegration

Identifiers

PMID31194022
PMCPMC6551367

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.