Evidence map›Paper›PMID 31193882›Full record

ArticleJournal of traditional and complementary medicine2019

Evaluation of selected traditional Chinese medical extracts for bone mineral density maintenance: A mechanistic study.

John F Rebhun, Qin Du, Molly Hood, Hailing Guo, Kelly M Glynn, Hao Cen, Jeffrey D Scholten, Feng Tian, Min Gui, Minjie Li and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The Role of Herbal Medicine in Modulating Bone Homeostasis.Current topics in medicinal chemistry · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

John F RebhunDepartment of Analytical Sciences, Nutrilite Health Institute, Ada, MI, 49355, USA.
Qin DuDepartment of Nutrition & Science Group, Nutrilite Health Institute, Shanghai, 201203, China.
Molly HoodDepartment of Analytical Sciences, Nutrilite Health Institute, Ada, MI, 49355, USA.
Hailing GuoResearch Institute of Orthopaedics & Trauma, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Kelly M GlynnDepartment of Analytical Sciences, Nutrilite Health Institute, Ada, MI, 49355, USA.
Hao CenDepartment of Nutrition & Science Group, Nutrilite Health Institute, Shanghai, 201203, China.
Jeffrey D ScholtenDepartment of Analytical Sciences, Nutrilite Health Institute, Ada, MI, 49355, USA.
Feng TianDepartment of Nutrition & Science Group, Nutrilite Health Institute, Shanghai, 201203, China.
Min GuiDepartment of Nutrition & Science Group, Nutrilite Health Institute, Shanghai, 201203, China.
Minjie LiDepartment of Nutrition & Science Group, Nutrilite Health Institute, Shanghai, 201203, China.
Yongfang ZhaoResearch Institute of Orthopaedics & Trauma, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shanghai Institute of Nutrition and Health · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the development of a minimal traditional Chinese medicine (TCM) formula using selected TCM ingredients and evaluating their biological activity with bone-specific METHODS AND

resultsSixteen different TCM plant extracts were tested for estrogenic, osteogenic and osteoclastic activities. Despite robust activation of the full-length estrogen receptors α and β by

conclusionA minimal formula consisting of TCM plant extracts that activate CRE and inhibit of NF-κβ activation, but do not behave like estrogen, maintain BMD in a LBM/OP model system.

Indexed as

Anti-inflammatoryBMD, bone mineral densityBmp4, bone morphogenic protein 4BSA, bovine serum albumincAMP, cyclic adenosine monophosphateCREB, cyclic adenosine monophosphate response element binding proteinCRE, cyclic adenosine monophosphate response elementDEXA, dual-energy X-ray absorptiometryDMSO, Dimethyl sulfoxideDrynaria fortuneiE2, estradiolEpimedium brevicornuERE, estrogen response elementER, estrogen receptorEstrogenicFBS, fetal bovine serumFsk, forskolinHprt, hypoxanthine-guanine phosphoribosyl-transferaseIL-1, interleukin 1LBD, ligand binding domainLBM, low bone massMAPK, mitogen activated protein kinaseM-CSF, macrophage colony-stimulating factorNF-κβ, nuclear factor kappa betaOP, osteoporosisOsteoporosisPTH, parathyroid hormonePTHrp, PTH related peptideqPCR, quantitative polymerase chain reactionRANKL, receptor activator of nuclear factor kappa beta ligandRLU, relative luminescence unitROI, region of interestRunx2, runt-related transcription factor 2SFM, serum free mediaTCM, traditional Chinese medicineTNFα, tumor necrosis factor alphaTRAP, tartrate-resistant acid phosphataseUAS, upstream activating sequence

Identifiers

PMID31193882
PMCPMC6544583
OpenAlexW2893366348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.