Evidence map›Paper›PMID 31193773›Full record

ArticleActa pharmaceutica Sinica. B2019

Aurone derivatives as Vps34 inhibitors that modulate autophagy.

Guodong Li, Joshua William Boyle, Chung-Nga Ko, Wu Zeng, Vincent Kam Wai Wong, Jian-Bo Wan, Philip Wai Hong Chan, Dik-Lung Ma, Chung-Hang Leung

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Guodong LiState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
Joshua William BoyleSchool of Chemistry, Monash University, Clayton 3800, Australia.
Chung-Nga KoDepartment of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China.
Wu ZengState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Vincent Kam Wai WongState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Jian-Bo WanState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
Philip Wai Hong ChanSchool of Chemistry, Monash University, Clayton 3800, Australia.
Dik-Lung MaDepartment of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China.
Chung-Hang LeungState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
University of Macau · MOHong Kong Baptist University · HKMacau University of Science and Technology · MOMonash University · AUUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report in this study the identification of a natural product-like antagonist (

Indexed as

Aurone derivativeAutophagyCETSA, cellular thermal shift assayCo-IP, co-immunoprecipitationDMEM, Dulbecco׳s modified Eagle׳s mediumDMSO, dimethyl sulfoxideEBSS, Earle׳s balanced salt solutionELISA, enzyme-linked immunosorbent assayFBS, fetal bovine serumHeart or liver damageInhibitorNatural productsPE, phosphatidylethanolaminePI3K, phosphoinositide 3-kinasePI3P, phosphatidylinositol 3-phosphatePI, phosphatidylinositolPS, phosphatidylserineStructure-based virtual screeningVesicle traffickingVps34

Identifiers

PMID31193773
PMCPMC6543056
OpenAlexW2913543432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.