ArticleEClinicalMedicine2019
Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status.
Article in EClinicalMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04399096 (Sound and Vision), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sound and Vision: A Collaboration Between Service-users, Artists and the Public to Explore the Lived Experience of Hallucinations
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Hallucinations and auditory-verbal signal detection studies: A meta-analytic review.Psychological medicine · 2026Pooled it
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Hearing voices and other altered perceptual experiences across psychotic, mood, and anxiety disorders: from phenomenology and mechanisms to future directions.Schizophrenia (Heidelberg, Germany) · 2025Review
- Changes of brain structure and structural covariance networks in Parkinson's disease with different sides of onset.Frontiers in aging neuroscience · 2025Article
- Study protocol for identifying resting brain functional connectivity markers of response to continuous Theta Burst Stimulation and cathodal transcranial Direct Current Stimulation in patients with schizophrenia with persistent auditory hallucinations.Wellcome open research · 2024Article
- A multicentre study on grey matter morphometric biomarkers for classifying early schizophrenia and parkinson's disease psychosis.NPJ Parkinson's disease · 2023Article
- Structural and Functional Imaging Correlates of Visual Hallucinations in Parkinson's Disease.Current neurology and neuroscience reports · 2023Review
- Baseline cerebral structural morphology predict freezing of gait in early drug-naïve Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination.Translational psychiatry · 2022Article
- Longitudinal thalamic white and grey matter changes associated with visual hallucinations in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Superior temporal gyrus functional connectivity predicts transcranial direct current stimulation response in Schizophrenia: A machine learning study.Frontiers in psychiatry · 2022Article
- Hypersensitivity to passive voice hearing in hallucination proneness.Frontiers in human neuroscience · 2022Article
- Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease.Annals of clinical and translational neurology · 2021Article
- Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank).Translational psychiatry · 2021Article
- Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.Translational psychiatry · 2020Article
- Psychosis in Parkinson's disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges.Acta pharmacologica Sinica · 2020Review
- Are Neuroanatomical Abnormalities Underlying Hallucinations Modality-specific?EClinicalMedicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHallucinations are transmodal and transdiagnostic phenomena, occurring across sensory modalities and presenting in psychiatric, neurodegenerative, neurological, and non-clinical populations. Despite their cross-category occurrence, little empirical work has directly compared between-group neural correlates of hallucinations.
methodsWe performed whole-brain voxelwise meta-analyses of hallucination status across diagnoses using anisotropic effect-size seed-based
findings3214 abstracts were identified. Patients with psychiatric disorders and hallucinations (eight studies) exhibited reduced gray matter (GM) in the left insula, right inferior frontal gyrus, left anterior cingulate/paracingulate gyrus, left middle temporal gyrus, and increased in the bilateral fusiform gyrus, while patients with neurodegenerative disorders with hallucinations (eight studies) showed GM decreases in the left lingual gyrus, right supramarginal gyrus/parietal operculum, left parahippocampal gyrus, left fusiform gyrus, right thalamus, and right lateral occipital gyrus. Group differences between psychiatric and neurodegenerative hallucination meta-analyses were formally confirmed using Monte Carlo randomizations to determine statistical significance, and a jackknife sensitivity analysis established the reproducibility of results across nearly all study combinations. For other structural measures (28 studies), the most consistent findings associated with hallucination status were reduced cortical thickness in temporal gyri in schizophrenia and altered hippocampal volume in Parkinson's disease and dementia. Additionally, increased severity of hallucinations in schizophrenia correlated with GM reductions within the left superior temporal gyrus, right middle temporal gyrus, bilateral supramarginal and angular gyri.
interpretationDistinct patterns of neuroanatomical alteration characterize hallucination status in patients with psychiatric and neurodegenerative diseases, suggesting a plurality of anatomical signatures. This approach has implications for treatment, theoretical frameworks, and generates refutable predictions for hallucinations in other diseases and their occurrence within the general population.
fundingNone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.