ArticleEClinicalMedicine2019
Statins and Risk of Intracerebral Haemorrhage in a Stroke-Free Population: A Nationwide Danish Propensity Score Matched Cohort Study.
Article in EClinicalMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- A Low LDL-C Level but not Statin Use is Associated with In-hospital Mortality in Spontaneous Intracerebral Hemorrhage; The J-ICH Registry.Journal of atherosclerosis and thrombosis · 2026Article
- A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies.Frontiers in immunology · 2025Review
- A new score for predicting intracranial hemorrhage in patients using antiplatelet drugs.Annals of hematology · 2024Article
- Interpersonal violent injury and subsequent risk of suicide and deliberate self-harm: a register-based national cohort study from Norway, 2010-2018.EClinicalMedicine · 2024Article
- Association Between Statin Use and Intracerebral Hemorrhage Location: A Nested Case-Control Registry Study.Neurology · 2023Article
- Tissue Engineering and Targeted Drug Delivery in Cardiovascular Disease: The Role of Polymer Nanocarrier for Statin Therapy.Biomedicines · 2023Review
- Mapping Outcomes and Registries Used in Current Danish Pharmacoepidemiological Research.Clinical epidemiology · 2022Review
- Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier.Cells · 2021Review
- Do statins reduce the mortality rate in stroke patients treated with systemic thrombolysis in a 5-year.Neural regeneration research · 2021Article
- Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke.Risk management and healthcare policy · 2021Article
- Cerebrovascular Disease and Statins.Frontiers in cardiovascular medicine · 2021Review
- Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang.Frontiers in cellular neuroscience · 2021Article
- Death of a Partner and Risks of Ischemic Stroke and Intracerebral Hemorrhage: A Nationwide Danish Matched Cohort Study.Journal of the American Heart Association · 2020Article
- Optimization of risk stratification for anticoagulation-associated intracerebral hemorrhage: net risk estimation.Journal of neurology · 2020Article
- Role of Statin Therapy in Primary Prevention of Cardiovascular Disease in Elderly Patients.Current atherosclerosis reports · 2019Review
- Reduced Risk of Intracerebral Haemorrhage from Statins: Added-Value of Large Healthcare Data.EClinicalMedicine · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStatins may increase the risk of intracerebral haemorrhage (ICH) in individuals with previous stroke. It remains unclear whether this applies to individuals with no history of stroke. This study is the first to explore the statin-associated risk of ICH in stroke-free individuals while considering the timing of statin initiation.
methodsWe conducted a population-based, propensity score matched cohort study using information from five Danish national registers. We included all stroke-free individuals initiating statins in 2004-2013 and a propensity score matched group of non-users. Adjusted hazard ratios (aHRs) for ICH risk among statin users compared to non-users were calculated as a function of time since statin initiation.
findings519,894 stroke-free individuals initiating statins and their 1:5 matched stroke-free reference subjects were included and followed for up to ten years. During this period, 1409 ICHs occurred in statin users. Statin users had an overall aHR of 0.85 (95% confidence interval: 0.80-0.90) compared to non-users, but this risk was modified by time since statin initiation. Statin users and non-users had similar ICH risk during the first six months after statin initiation. Hereafter, statin users had a 22-35% lower risk throughout the study period.
interpretationStatin users had lower ICH risk than non-users from six months after statin initiation. This finding could not be explained by healthy initiator bias or differences between users and non-users in terms of sociodemographic characteristics, comorbidity, or parallel treatment regimens. Our study suggests that statin use in stroke-free populations is associated with reduced ICH risk.
fundingThe Novo Nordisk Foundation.
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