ArticleEClinicalMedicine
Syndemic Characterization of HCV, HBV, and HIV Co-infections in a Large Population Based Cohort Study.
Article in EClinicalMedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Describing trends of sexually transmitted blood borne co-infections in Nova Scotia from 2019 to 2023.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Seroprevalence and Early Indicators of HBV and HCV Co-infection Among Newly Diagnosed HIV Patients: A Cross-Sectional Study from India.AIDS and behavior · 2026Article
- Sexually transmitted and blood-borne infection syndemics in Ontario: A population-based retrospective study of iPHIS data (2013-2023).Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- The hepatitis B care cascade among key populations towards global elimination: a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2026Article
- The role of tenofovir-based HIV pre-exposure prophylaxis in preventing HBV infection among men who have sex with men: insights from China.Infectious diseases of poverty · 2025Article
- Approaches to Offering Hepatitis C Treatment at Syringe Services Programs in the United States: A Scoping Review.Open forum infectious diseases · 2025Review
- Attitudes Toward and Beliefs in the Effectiveness of Biomedical HIV Prevention Strategies Among Emerging and Young Adult Sexual Minority Men.International journal of behavioral medicine · 2025Article
- Syndemic geographic patterns of integrated diseases during the Libyan armed conflict; a new aspect for public health care intervention?Frontiers in epidemiology · 2025Article
- Self-reported hepatitis B testing among noninstitutionalized adults in the United States before the implementation of universal screening, 2013-2017: A nationwide population-based study.Journal of viral hepatitis · 2024Article
- A systematic review and guide for using multi-response statistical models in co-infection research.Royal Society open science · 2024Article
- Canadian Association for the Study of the Liver Single Topic Conference on Hepatitis B Virus: 'Progress toward hepatitis B elimination in Canada'.Canadian liver journal · 2024Article
- Injection drug use and sexually transmitted infections among men who have sex with men: A retrospective cohort study at an HIV/AIDS referral hospital in Tokyo, 2013-2022.Epidemiology and infection · 2023Article
- Article
- Advancing virtual primary care for people with opioid use disorder (VPC OUD): a mixed-methods study protocol.BMJ open · 2022Article
- Impact of COVID-19-related public health measures on HCV testing in British Columbia, Canada: An interrupted time series analysis.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Epidemiological trends of HBV and HDV coinfection among Viennese HIV+ patients.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Syndemic Profiles and Sexual Minority Men's HIV-Risk Behavior: A Latent Class Analysis.Archives of sexual behavior · 2021Article
- Influence of chronic hepatitis C infection on the monocyte-to-platelet ratio: data analysis from the National Health and Nutrition Examination Survey (2009-2016).BMC public health · 2021Article
- Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada.Therapeutic advances in medical oncology · 2021Article
- Drug-related deaths in a population-level cohort of people living with and without hepatitis C virus in British Columbia, Canada.The International journal on drug policy · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited data are available on HBV, HCV, and HIV co-infections and triple infection. We characterized co-occurrence of HIV, HBV, and HCV infections at the population level in British Columbia (BC) to identify patterns of predisposing factors unique to co-infection subgroups.
methodsWe analyzed data from the BC Hepatitis Testers Cohort, which includes all individuals tested for HCV or HIV in BC between 1992 and 2013, or included in provincial public health registries of HIV, HCV, HBV, and active tuberculosis. Individuals were classified as negative, mono-, and co-infection groups based on HIV, HBV, and HCV status. We evaluated associations between risk factors (injection drug use, sexual orientation etc.) and co-infection groups using multivariate multinomial logistic regression.
findingsOf a total of 1,376,989 individuals included in the analysis, 1,276,290 were negative and 100,699 were positive for HIV, HBV, and/or HCV. Most cases (91,399, 90.8%) were mono-infected, while 3991 (4.0%) had HBV/HCV, 670 HBV/HIV (0.7%), 3459 HCV/HIV (3.4%), and 1180 HBV/HCV/HIV (1.2%) co-infection. Risk factor and demographic distribution varied across co-infection categories. MSM classification was associated with higher odds of all HIV co-infection groups, particularly HBV/HIV (OR 6.8; 95% CI: 5.6, 8.27), while injection drug use was most strongly associated with triple infection (OR 64.19; 95% CI: 55.11, 74.77) and HIV/HCV (OR 23.23; 95% CI: 21.32, 25.31).
interpretationSyndemics of substance use, sexual practices, mental illness, socioeconomic marginalization, and co-infections differ among population groups, highlighting avenues for optimal composition and context for health services to meet each population's unique needs.
fundingBC Centre for Disease Control and Canadian Institutes of Health Research.
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