ArticlePreventive medicine reports2019
Associations of smoking indicators and cotinine levels with telomere length: National Health and Nutrition Examination Survey.
Article in Preventive medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Telomere Length in Celiac Disease in a Population-Based Cohort: A HUNT Study.Clinical and translational gastroenterology · 2026Article
- Association between blood heavy metals and diabetic kidney disease among type 2 diabetic patients: a cross-sectional study.Scientific reports · 2024Article
- Article
- Associations of lifestyle characteristics with circulating immune markers in the general population based on NHANES 1999 to 2014.Scientific reports · 2024Article
- Feasibility of mailed biomarker data collection among U.S. young adults: Saliva-based cotinine and self-reported nicotine use.Drug and alcohol dependence · 2023Article
- A Time-Varying Effect Model (TVEM) of the Complex Association of Tobacco Use and Smoke Exposure on Mean Telomere Length: Differences between Racial and Ethnic Groups Assessed in the National Health and Nutrition Examination Survey.International journal of environmental research and public health · 2022Article
- Strategies for understanding the role of cellular heterogeneity in the pathogenesis of lung cancer: a cell model for chronic exposure to cigarette smoke extract.BMC pulmonary medicine · 2022Article
- Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study.Journal of racial and ethnic health disparities · 2022Article
- Association of circulating leukocyte telomere length with survival in patients with colorectal cancer.Journal of geriatric oncology · 2022Article
- Impact of prenatal tobacco smoking on infant telomere length trajectory and ADHD symptoms at 18 months: a longitudinal cohort study.BMC medicine · 2022Article
- Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis.Frontiers in nutrition · 2022Article
- Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies.Journal of clinical medicine · 2021Review
- Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study.Healthcare (Basel, Switzerland) · 2021Article
- Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association.Frontiers in aging neuroscience · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of smoking exposure on telomere length with a focus on the impact of race has rarely been discussed. We performed a cross sectional analysis into the associations of smoking indicators with leukocyte telomere length (LTL) by race among 5864 nationally representative sample of US adults (≥20 years). Data from 1999 to 2002 National Health and Nutrition Examination Survey was used for the analysis. Smoking indicators were assessed by interviews and serum cotinine levels. LTL was quantified by polymerase chain reaction. Multiple linear regressions were used to assess the association with adjustment for covariates, sample weights and design effects separately for Whites, Blacks and Mexican Americans. The intensity of smoking, measured by the average number of cigarettes consumed per day, was negatively associated with LTL among Whites (β: -3.87, 95% CI: -5.98 to -1.21) and among Blacks (β: -15.46, 95% CI: -29.79 to -2.12) participants. Compared with cotinine level < 0.05 ng/ml, cotinine level ≥3 ng/ml was associated with shorter LTL (β: -77.92, 95% CI = -143.05 to -11.70) among Whites, but not among Blacks. We found increased number of cigarette consumption to be associated with shorter LTL in both Blacks and Whites, indicating that the impact of smoking on life-shortening diseases could partly be explained by telomere biology. Increased cotinine concentration however, was associated with shorter LTL only among Whites, not among Blacks. This differential relationship that we observed may have implications in interpreting cotinine as an objective biomarker of smoking exposure across races and warrant additional prospective investigation.
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