Evidence map›Paper›PMID 31193542›Full record

ArticleBone reports2019

Inhibition of vascular endothelial growth factor in young adult mice causes low bone blood flow and bone strength with no effect on bone mass in trabecular regions.

N E Lane, J S Nyman, S Uppuganti, A J Chaudhari, J I Aguirre, K Shidara, X P Liu, W Yao, D B Kimmel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Identifying Bone Matrix Impairments in a Mouse Model of Neurofibromatosis Type 1 (NF1) by Clinically Translatable Techniques.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

N E LaneCenter for Musculoskeletal Health, University of California at Davis Medical Center, Sacramento, CA 95817, USA.
J S NymanDepartment of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
S UppugantiDepartment of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
A J ChaudhariCenter for Molecular and Genomic Imaging, Department of Radiology, University of California at Davis, Davis, CA 95616, USA.
J I AguirreDepartment of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA.
K ShidaraCenter for Musculoskeletal Health, University of California at Davis Medical Center, Sacramento, CA 95817, USA.
X P LiuCenter for Musculoskeletal Health, University of California at Davis Medical Center, Sacramento, CA 95817, USA.
W YaoCenter for Musculoskeletal Health, University of California at Davis Medical Center, Sacramento, CA 95817, USA.
D B KimmelDepartment of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA.
University of California Davis Medical Center · USUniversity of Florida · USVanderbilt University Medical Center · USUniversity of California, Davis · US

Funding

Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2015
$6.2M
3D IN VIVO MORPHOMETRY OF TRABECULAR MICROSTRUCTURER01AR043052 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI LANE, NANCY E · 1995 to 2014
$5.0M
Matrix-Sensitive Tools for Detecting NF1-Related Changes in Bone QualityR21AR072483 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELEFTERIOU, FLORENT, NYMAN, JEFFRY STEPHEN · 2018 to 2019
$408k
NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR043052NIAMS NIH HHS R21 AR072483
6 · The paper itself

Abstract

objectiveTo determine the effect of an antibody to vascular endothelial growth factor (VEGF) on bone blood flow, bone strength, and bone mass in the young adult mouse.

methodsTen-week-old male BALB/cJ mice were body weight-randomized into either a rodent anti-VEGF monoclonal antibody (anti-VEGF, B20-4.1.1; 5 mg/kg 2×/wk.; n = 12) group or a vehicle (VEH; n = 12) group. After 42 days, mice were evaluated for bone blood flow at the distal femur by

resultsDistal femur blood flow was 43% lower in anti-VEGF mice than in VEH mice (p = 0.009). Ultimate load in the lumbar vertebral body was 25% lower in anti-VEGF than in VEH mice (p = 0.013). Bone mineral density (BMD) in the trabecular region of the proximal humeral metaphysis by pQCT, and bone volume fraction and volumetric BMD by MicroCT were the same in the two groups. Volume fraction of bound water (BW) of the whole femur was 14% lower in anti-VEGF than in VEH mice (p = 0.003). Finally, BW, but not cortical tissue mineral density, helped section modulus explain the variance in the ultimate moment experienced by the femur in three-point bending.

conclusionAnti-VEGF caused low bone blood flow and bone strength in trabecular bone regions without influencing BMD and microarchitecture. Low bone strength was also associated with low bone hydration. These data suggest that bone blood flow is a novel bone property that affects bone quality.

Indexed as

18F-NaF-PET/CTAnti-VEGF antibodyBone mineral density (BMD)Bone qualityBone waterCorticalMicroarchitectureTrabecularUltimate load

Identifiers

PMID31193542
PMCPMC6535464
OpenAlexW2944245850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.