ArticleNeurobiology of stress2019
The mediating role of hippocampal networks on stress regulation in amnestic mild cognitive impairment.
Article in Neurobiology of stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis.Ageing research reviews · 2022Pooled it
- Prefrontal activity and heart rate variability during cognitive tasks may show different changes in young and older adults with and without mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder.Neuropsychiatric disease and treatment · 2024Article
- Autonomic nervous system flexibility for understanding brain aging.Ageing research reviews · 2023Review
- CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI.GeroScience · 2023Article
- Aging-related changes in reward-based decision-making depend on punishment frequency: An fMRI study.Frontiers in aging neuroscience · 2023Article
- Shared alterations in hippocampal structural covariance in subjective cognitive decline and migraine.Frontiers in aging neuroscience · 2023Article
- Altered small-world property of a dynamic metabolic network in murine left hippocampus after exposure to acute stress.Scientific reports · 2022Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the role of the hippocampus in stress regulation in older adults with amnestic mild cognitive impairment (aMCI).
methodsThis study combined resting-state functional MRI, structural MRI, self-reported chronic stress exposure, and an electrocardiography-based acute stress protocol to compare aMCI group (n = 17) to their cognitively healthy counterparts (HC, n = 22).
resultsFor the entire sample, there was a positive correlation between chronic stress exposure and acute stress regulation. The aMCI group showed significantly smaller volumes in the right hippocampus than HC. The two groups did not differ in chronic stress exposure or acute stress regulation. In the HC group, the left hippocampal connectivity with inferior parietal lobe was significantly correlated with both the chronic stress and acute stress. In the aMCI group, the left hippocampal connectivity with both the right insula and the left precentral gyrus was significantly correlated to chronic stress exposure and acute stress regulation. Additionally, the left hippocampal connectivity with right insula significantly mediated the relationship between chronic stress exposure and acute stress regulation in aMCI group.
conclusionsExtra hippocampal networks may be recruited as compensation to attend the maintenance of relatively normal stress regulation in aMCI by alleviating the detrimental effects of chronic stress exposure on acute stress regulation.
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