ArticleHeliyon2019
Synthesis and characterization of Zn-Doped hydroxyapatite: scaffold application, antibacterial and bioactivity studies.
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- AI for bioactive materials: From material design to biological applications.Bioactive materials · 2026Review
- Biomimetic electrospun nanofibrous composites for bone tissue engineering: a review of materials, fabrication, and applications.Biomedical engineering online · 2026Review
- Synergistic effect of rare-earth and transition metal conversion coatings on bioactive hydroxyapatite mineralization and electrochemical behavior of AZ31 magnesium alloys.Scientific reports · 2026Article
- Biomimetic Deposition of Zn-Doped Calcium Phosphate Coatings on Surface-Activated Ti6Al4V for Multifunctional Implant Interfaces.Journal of functional biomaterials · 2026Article
- Zinc and hydroxyapatite co-localize during in vitro E. coli biofilms mineralization.Scientific reports · 2026Article
- Electrochemical Deposition and Characterisation of Silver-Containing Hydroxyapatite Coatings on Zinc: Influence of Silver Addition on the Functional Properties of a Biodegradable Implant System.International journal of biomaterials · 2026Article
- Microstructural characterization and osteogenic efficacy of PVA/PVP blended mineral scaffold for bone tissue engineering.Journal of materials science. Materials in medicine · 2025Article
- Zn-doped CaP coating equips Ti implants with corrosion resistance, biomineralization, antibacterial and immunotolerant activities.Journal of advanced research · 2025Article
- Advancements in zinc oxide nanofibers for enhanced rehabilitation and injury recovery: mechanisms, applications, and future directions.Journal of biological engineering · 2025Review
- Development and Physico-Chemical and Antibacterial Characterization of Chromium-Doped Hydroxyapatite in a Chitosan Matrix Coating.Polymers · 2025Article
- New Nanobioceramics Based on Hydroxyapatite for Biomedical Applications: Stability and Properties.Nanomaterials (Basel, Switzerland) · 2025Article
- Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects.International journal of nanomedicine · 2025Review
- Fabrication and Characterization of Electrospun Sr/Zn-Doped Nano-Hydroxyapatite-Collagen-PLGA Nanofibrous Scaffolds for Bone Tissue Engineering.International journal of nanomedicine · 2025Article
- Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.Regenerative biomaterials · 2025Review
- Revisiting Physicochemical and Biological Properties of ZnNanotechnology, science and applications · 2025Article
- Antibacterial Activity of Zinc-Doped Hydroxyapatite and Vancomycin-Loaded Gelatin Nanoparticles against IntracellularACS applied nano materials · 2024Article
- Evaluating various properties of nanohydroxyapatite synthesized from eggshells and dual-doped with SiHeliyon · 2024Article
- Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline.Antibiotics (Basel, Switzerland) · 2024Article
- Engineering antibacterial bioceramics: Design principles and mechanisms of action.Materials today. Bio · 2024Review
- Impacts of pre-treatment methods on the morphology, crystal structure, and defects formation of hydroxyapatite extracted from Nile tilapia scales.RSC advances · 2024Article
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Authors and funding
4 authors.
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Abstract
In this study, the antimicrobial and scaffold of zinc-substituted hydroxyapatite, (Zn-HAp) synthesized via chemical co-precipitation technique was investigated. The structure of the synthesized Zn-HAp was investigated with X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, Scanning electron microscope (SEM), Energy dispersive X-spectroscopy (EDAX), transmission electron microscope (TEM), Thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). Bioactivity study was performed in simulated body fluid (SBF), while the antimicrobial activity was studied using disc diffusion method. The XRD structure revealed that Zn ion incorporation up to 10% led to the second phase hydroxyapatite (HAp) formation, while higher concentration diminished the apatite structure. The presence of phosphate ions, carbonates ions, and hydroxyl groups in the apatite powder was ascertained by the FT-IR evaluation. SEM evaluation showed that the apatite contains fine particles with nearly round shape with interconnected pores and decreasing Ca/P ratio with increasing Zn ion concentration. TEM results showed particulate polycrystalline apatite with crystallite size ranging from 68 nm in pure HAp to 41 nm in 20% Zn-doped HAp indicating a decrease in the crystal size with increasing Zn ion in the samples. The bioactivity study showed spherical deposition around the porous region of the scaffold HAp suggesting the growth of apatite in SBF media after 7 days of incubation, while antibacterial activity studies showed zones of inhibition with an increase in zinc ions concentrations.
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