Evidence map›Paper›PMID 31193299›Full record

ArticleBone reports2019

Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect.

Sunita Sharma, Ying Xue, Zhe Xing, Mohammed A Yassin, Yang Sun, James B Lorens, Anna Finne-Wistrand, Dipak Sapkota, Kamal Mustafa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sunita SharmaDepartment of Clinical Dentistry, Faculty of Medicine, University of Bergen, Bergen, Norway.
Ying XueDepartment of Clinical Dentistry, Faculty of Medicine, University of Bergen, Bergen, Norway.
Zhe XingDepartment of Clinical Dentistry, Faculty of Medicine, University of Bergen, Bergen, Norway.
Mohammed A YassinDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Yang SunDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
James B LorensDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Anna Finne-WistrandDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Dipak SapkotaDepartment of Oral Biology, Faculty of Dentistry, 0316 Oslo, Norway.
Kamal MustafaDepartment of Clinical Dentistry, Faculty of Medicine, University of Bergen, Bergen, Norway.
University of Bergen · NOKTH Royal Institute of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apart from osteogenesis, neovascularization of the defect area is an important determinant for successful bone healing. Accordingly, several studies have employed the combined delivery of VEGFA and BMP2 for bone regeneration. Nevertheless, the outcomes of these studies are highly variable. The aim of our study was to compare the effectiveness of adenoviral mediated delivery of BMP2 alone and in combination with VEGFA in rat bone marrow stromal cells (rBMSC) seeded on a poly(LLA-

Indexed as

Bone tissue engineeringCopolymer scaffoldMesenchymal stem cellsMicroCT

Identifiers

PMID31193299
PMCPMC6525280
OpenAlexW2938749521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.