Evidence map›Paper›PMID 31193276›Full record

ArticleBiochemistry and biophysics reports2019

Differentiation of embryonic stem cells into inner ear vestibular hair cells using vestibular cell derived-conditioned medium.

Masaharu Sakagami, Yukiteru Ouji, Norikazu Kawai, Masayasu Misu, Masahide Yoshikawa, Tadashi Kitahara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Frailty of the.The journal of international advanced otology · 2024
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Masaharu SakagamiDepartment of Otolaryngology - Head and Neck Surgery, Nara Medical University, Kashihara, Nara, Japan.
Yukiteru OujiDepartment of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Nara, Japan.
Norikazu KawaiDepartment of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Nara, Japan.
Masayasu MisuDepartment of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Nara, Japan.
Masahide YoshikawaDepartment of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Nara, Japan.
Tadashi KitaharaDepartment of Otolaryngology - Head and Neck Surgery, Nara Medical University, Kashihara, Nara, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vestibular hair cells (V-HCs) in the inner ear have important roles and various functions. When V-HCs are damaged, crippling symptoms, such as vertigo, visual field oscillation, and imbalance, are often seen. Recently, several studies have reported differentiation of embryonic stem (ES) cells, as pluripotent stem cells, to HCs, though a method for producing V-HCs has yet to be established. In the present study, we used vestibular cell conditioned medium (V-CM) and effectively induced ES cells to differentiate into V-HCs. Expressions of V-HC-related markers (

Indexed as

Conditioned mediumDifferentiationEmbryonic stem cellsHair cellsInner earVestibular

Identifiers

PMID31193276
PMCPMC6525281
OpenAlexW2946349268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.