ArticleThe EMBO journal1987
The nuclear migration signal of Xenopus laevis nucleoplasmin.
Article in The EMBO journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 177 citations in OpenAlex.
- Structure-function relationship of H2A-H2B specific plant histone chaperones.Cell stress & chaperones · 2020Review
- CRISPR/Cas9 editing of three CRUCIFERIN C homoeologues alters the seed protein profile in Camelina sativa.BMC plant biology · 2019Article
- Nuclear localization of Japanese encephalitis virus core protein enhances viral replication.Journal of virology · 2005Article
- Localization of HB9 homeodomain protein and characterization of its nuclear localization signal during chick embryonic skin development.Histochemistry and cell biology · 2004Article
- Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe.Molecular biology of the cell · 2004Article
- Expression patterns and subcellular localization of a 52 kDa sucrose-binding protein homologue of Vicia faba (VfSBPL) suggest different functions during development.Plant molecular biology · 2001Article
- Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
- Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.The EMBO journal · 1996Article
- The N-terminus of fission yeast DNA polymerase alpha contains a basic pentapeptide that acts in vivo as a nuclear localization signal.Molecular biology of the cell · 1995Article
- Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A nuclear localization domain in the hnRNP A1 protein.The Journal of cell biology · 1995Article
- Nucleocytoplasmic transport.The Biochemical journal · 1994Review
- The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.The EMBO journal · 1994Article
- Article
- The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family.The Journal of cell biology · 1993Article
- Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.The Journal of cell biology · 1993Article
- Mutations in a 19-amino-acid hydrophobic region of the yeast cytochrome c1 presequence prevent sorting to the mitochondrial intermembrane space.Molecular and cellular biology · 1992Article
- The T-DNA-linked VirD2 protein contains two distinct functional nuclear localization signals.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein.The Journal of cell biology · 1992Article
- Distal protein sequences can affect the function of a nuclear localization signal.Molecular and cellular biology · 1992Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleoplasmin is the most abundant protein in the nucleus of Xenopus laevis oocytes. Its ability to target to the nucleus when microinjected into the cytoplasm has been the subject of many studies central to our understanding of how proteins segregate into nuclei. Using a cDNA clone we constructed beta-galactosidase-nucleoplasmin hybrids in modified bacterial expression vectors. The fusion proteins were expressed in Escherichia coli, purified and injected into the cytoplasm of X. laevis oocytes. The distribution of the fusion proteins between the cytoplasmic and nuclear compartments were analysed after incubation of various lengths of time. The results show that the signal sequence for nuclear transport is located close to the carboxy terminus of the protein. The signal sequence has been mapped to a small stretch of amino acids, containing a stretch of four lysines analogous to the SV40 large-T antigen signal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.