ArticleMedicine2019
Antibiotic resistance profiles and multidrug resistance patterns of Streptococcus pneumoniae in pediatrics: A multicenter retrospective study in mainland China.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Global trends in macrolide and lincosamide resistance in Streptococcus species: a comprehensive systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- A systematic review of antimicrobial therapy in children with tracheostomies.Pediatric pulmonology · 2024Pooled it
- Antibiotic resistance patterns and resistance-associated genes in Streptococcus pneumoniae: insights from healthy children.Molecular biology reports · 2026Article
- Global Antimicrobial Non-Susceptibility Patterns ofInfection and drug resistance · 2026Review
- Case Report: Omadacycline in the Treatment of Community-Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies.Clinical case reports · 2025Article
- Genomic analysis of invasive and non-invasive disease-causingMicrobial genomics · 2025Article
- The Evolution of the Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2025Article
- Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae.PloS one · 2025Article
- Identification of cell wall binding domains and repeats inBiochemistry and biophysics reports · 2024Article
- Assessment of the pattern of antibiotic resistance among microorganisms isolated from the culture medium prepared from hospitalized patients: A retrospective study.Journal of family medicine and primary care · 2024Article
- Serotype, antibiotic susceptibility and whole-genome characterization ofFrontiers in microbiology · 2024Article
- In silico design of an epitope-based vaccine against PspC in Streptococcus pneumoniae using reverse vaccinology.Journal, genetic engineering & biotechnology · 2023Article
- Discovery of novel phenanthridone derivatives with anti-streptococcal activity.Archives of microbiology · 2023Article
- In Silico Subtractive Proteomics and Molecular Docking Approaches for the Identification of Novel Inhibitors againstLife (Basel, Switzerland) · 2023Article
- Antibiotic Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Genomic Epidemiology ofPathogens (Basel, Switzerland) · 2023Article
- Nasopharyngeal carriage and antimicrobial susceptibility profiles ofAccess microbiology · 2023Article
- Severe problem of macrolides resistance to common pathogens in China.Frontiers in cellular and infection microbiology · 2023Review
- A Hospital-Based and Cross-Sectional Investigation on Clinical Characteristics of PediatricInfection and drug resistance · 2023Article
- An Overview of Macrolide Resistance in Streptococci: Prevalence, Mobile Elements and Dynamics.Microorganisms · 2022Review
Corrections and comments
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Authors and funding
26 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide. Antibiotic resistance profiles for S pneumoniae isolates identified from pediatric patients in mainland China remains to be established.The clinical features, antimicrobial resistance, and multidrug resistance patterns of S pneumoniae were retrospectively analyzed at 10 children's hospitals in mainland China in 2016.Among the collected 6132 S pneumoniae isolates, pneumococcal diseases mainly occurred in children younger than 5 years old (85.1%). The resistance rate of S pneumoniae to clindamycin, erythromycin, tetracycline, and trimethoprim/sulfamethoxazole was 95.8%, 95.2%, 93.6%, and 66.7%, respectively. The resistance rates of S pneumoniae to penicillin were 86.9% and 1.4% in non-meningitis and meningitis isolates, while the proportions of ceftriaxone resistance were 8.2% and 18.1%, respectively. Pneumococcal conjugate vaccine was administered to only 4.1% of patients. Penicillin and ceftriaxone resistance, underling diseases, antibiotic resistant risk factors, and poor prognosis appeared more frequently in invasive pneumococcal diseases. The incidence of multidrug resistance (MDR) was 46.1% in patients with invasive pneumococcal disease which was more than in patients with non-invasive pneumococcal disease (18.3%). Patients with invasive pneumococcal disease usually have several MDR coexistence.S pneumoniae isolates showed high resistance to common antibiotics in mainland China. Penicillin and ceftriaxone resistance rate of invasive streptococcal pneumonia patients were significantly higher than that of non-invasive S pneumoniae patients. Alarmingly, 46.1% of invasive clinical isolates were multidrug resistant, so it is important to continued monitor the resistance of S pneumoniae when protein conjugate vaccine (PCV13) is coming in mainland China.
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