ArticleClinical and translational gastroenterology2019
Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography.
Article in Clinical and translational gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Three-dimensional ex-vivo visualization of normal and inflamed small intestine and colonic tissue using optical coherence tomography.Scientific reports · 2026Article
- Development of an AI-Assisted System for Automatic Recognition and Localization Marking of Colonic Polyps (With Video).Journal of gastroenterology and hepatology · 2025Article
- A Partially Randomized Diagnostic Trial of OCT-EUS Integration: Enhancing Surgical Margin Delineation and Lymph Node Dissection in Oncological Resection.Clinical Medicine Insights. Oncology · 2025Article
- Evaluation of a novel forward-looking optical coherence tomography probe for endoscopic applications: an ex vivo feasibility study.Surgical endoscopy · 2024Article
- In vivo evaluation of complex polyps with endoscopic optical coherence tomography and deep learning during routine colonoscopy: a feasibility study.Scientific reports · 2024Article
- High-resolution rectoscopy using MHz optical coherence tomography: a step towards real time 3D endoscopy.Scientific reports · 2024Article
- Towards targeted colorectal cancer biopsy based on tissue morphology assessment by compression optical coherence elastography.Frontiers in oncology · 2023Article
- Differential diagnosis of acute and chronic colitis in mice by optical coherence tomography.Quantitative imaging in medicine and surgery · 2022Article
- The Status of Advanced Imaging Techniques for Optical Biopsy of Colonic Polyps.Clinical and translational gastroenterology · 2020Review
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16 authors.
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Abstract
introduction"Resect and discard" paradigm is one of the main strategies to deal with colorectal diminutive polyps after optical diagnosis. However, there are risks that unrecognized potentially malignant lesions are discarded without accurate diagnosis. The purpose of this study is to validate the potential of micro-optical coherence tomography (μOCT) to improve the diagnostic accuracy of colorectal lesions and help endoscopists make better clinical decision without additional pathology costs.
methodsFresh tissue samples were obtained from patients with colorectal polyps or colorectal cancer who received endoscopic therapy or laparoscopic surgery. These samples were instantly imaged by μOCT and then sent to pathological evaluation. Then, μOCT images were compared with corresponding HE sections. We created consensus μOCT image criteria and then tested to determine sensitivity, specificity, and accuracy of our system to discriminate neoplastic polyps from non-neoplastic polyps.
resultsOur μOCT system achieved a resolution of 2.0 μm in both axial and lateral directions, clearly illustrated both cross-sectional and en face subcellular-level microstructures of colorectal lesions ex vivo, demonstrating distinctive patterns for inflammatory granulation tissue, hyperplastic polyp, adenoma, and cancerous tissue. For the 58 cases of polyps, the accuracy of the model was 94.83% (95% confidence interval [CI], 85.30%-98.79%), the sensitivity for identification of adenomas was 96.88% (95% CI, 82.89%-99.99%), and the specificity was 92.31% (95% CI, 74.74%-98.98%). Our diagnostic criteria could help both expert endoscopists and nonexpert endoscopists to identify neoplastic from non-neoplastic polyps with satisfactory accuracy and good interobserver agreement. DISCUSSION: We propose a new strategy using μOCT to differentiate benign polyps and adenomas after the lesions are resected. The application of μOCT can potentially reduce the cost of pathological examination and minimize the risk of discarding malignant lesions during colonosocpy examination.
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