Evidence map›Paper›PMID 31192306›Full record

ArticleAPL photonics2018

Invited Article: Digital refocusing in quantitative phase imaging for flowing red blood cells.

Han Sang Park, Silvia Ceballos, Will J Eldridge, Adam Wax

Abstract read
In one paragraph

Article in APL photonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Han Sang ParkDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Silvia CeballosDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Will J EldridgeDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.

Funding

High throughput cell screening for toxic metal exposureR21ES029791 · NIEHS · DUKE UNIVERSITY · PI WAX, ADAM · 2018 to 2019
$403k
NIEHS NIH HHS R21 ES029791
6 · The paper itself

Abstract

Quantitative phase imaging (QPI) offers high optical path length sensitivity, probing nanoscale features of live cells, but it is typically limited to imaging just few static cells at a time. To enable utility as a biomedical diagnostic modality, higher throughput is needed. To meet this need, methods for imaging cells in flow using QPI are in development. An important need for this application is to enable accurate quantitative analysis. However, this can be complicated when cells shift focal planes during flow. QPI permits digital refocusing since the complex optical field is measured. Here we analyze QPI images of moving red blood cells with an emphasis on choosing a quantitative criterion for digitally refocusing cell images. Of particular interest is the influence of optical absorption which can skew refocusing algorithms. Examples of refocusing of holographic images of flowing red blood cells using different approaches are presented and analyzed.

Identifiers

PMID31192306
PMCPMC6561492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.