Evidence map›Paper›PMID 31192207›Full record

ArticleFrontiers in cell and developmental biology2019

Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research.

Massimo M Santoro, Monica Beltrame, Daniela Panáková, Arndt F Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung, Brant M Weinstein

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Central conducting lymphatic anomaly: from bench to bedside.The Journal of clinical investigation · 2024
    Review
  2. Article
  3. Use of Zebrafish in Drug Discovery Toxicology.Chemical research in toxicology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Massimo M SantoroLaboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy.
Monica BeltrameDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Daniela PanákováElectrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine, Helmholtz Association of German Research Centers (HZ), Berlin, Germany.
Arndt F SiekmannMax Planck Institute for Molecular Biomedicine, Münster, Germany.
Natascia TisoLaboratory of Developmental Genetics, Department of Biology, University of Padua, Padua, Italy.
Marina Venero GalanternikDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.
Hyun Min JungDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.
Brant M WeinsteinDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Padua · ITMax Delbrück Center · DEMax Planck Institute for Molecular Biomedicine · DEUniversity of Milan · IT

Funding

Specification And Patterning of Developing Blood VesselsZIAHD001011 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WEINSTEIN, BRANT · 2009 to 2025
$18.4M
Specification And Patterning of the Lymphatic SystemZIAHD008808 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WEINSTEIN, BRANT · 2009 to 2025
$9.2M
6 · The paper itself

Abstract

Since its introduction, the zebrafish has provided an important reference system to model and study cardiovascular development as well as lymphangiogenesis in vertebrates. A scientific workshop, held at the 2018 European Zebrafish Principal Investigators Meeting in Trento (Italy) and chaired by Massimo Santoro, focused on the most recent methods and studies on cardiac, vascular and lymphatic development. Daniela Panáková and Natascia Tiso described new molecular mechanisms and signaling pathways involved in cardiac differentiation and disease. Arndt Siekmann and Wiebke Herzog discussed novel roles for Wnt and VEGF signaling in brain angiogenesis. In addition, Brant Weinstein's lab presented data concerning the discovery of endothelium-derived macrophage-like perivascular cells in the zebrafish brain, while Monica Beltrame's studies refined the role of Sox transcription factors in vascular and lymphatic development. In this article, we will summarize the details of these recent discoveries in support of the overall value of the zebrafish model system not only to study normal development, but also associated disease states.

Indexed as

heartlymphatictrangenesisvascularzebrafish models

Identifiers

PMID31192207
PMCPMC6546721
OpenAlexW2947857319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.