Evidence map›Paper›PMID 31192159›Full record

ArticleFrontiers in cellular and infection microbiology2019

Immunomodulatory Effects of the Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide in Acute

Caio Andreeta Figueiredo, Henning Peter Düsedau, Johannes Steffen, Nishith Gupta, Miklos Pal Dunay, Gabor K Toth, Dora Reglodi, Markus M Heimesaat, Ildiko Rita Dunay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Caio Andreeta FigueiredoMedical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Henning Peter DüsedauMedical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Johannes SteffenMedical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Nishith GuptaFaculty of Life Sciences, Institute of Biology, Humboldt University, Berlin, Germany.
Miklos Pal DunayDepartment and Clinic of Surgery and Ophthalmology, University of Veterinary Medicine, Budapest, Hungary.
Gabor K TothDepartment of Medical Chemistry, University of Szeged, Szeged, Hungary.
Dora ReglodiDepartment of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, Pecs, Hungary.
Markus M HeimesaatDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Ildiko Rita DunayMedical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Otto-von-Guericke University Magdeburg · DECenter for Behavioral Brain Sciences · DECharité - Universitätsmedizin Berlin · DEHumboldt-Universität zu Berlin · DEUniversity of Pecs · HUUniversity of Szeged · HUUniversity of Veterinary Medicine · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide with distinct functions including the regulation of inflammatory processes. PACAP is able to modify the immune response by directly regulating macrophages and monocytes inhibiting the production of inflammatory cytokines, chemokines and free radicals. Here, we analyzed the effect of exogenous PACAP on peripheral immune cell subsets upon acute infection with the parasite

Indexed as

ImmunomodulationAnimalsAntigens, LyBrain-Derived Neurotrophic FactorChemokinesCytokinesDisease Models, AnimalFemaleHost-Pathogen InteractionsImmunity, InnateInflammationInterleukin-10MacrophagesMiceMice, Inbred C57BLNerve Growth FactorsAntigens, LyBrain-Derived Neurotrophic FactorChemokinesCytokinesIL10 protein, mouseInterleukin-10Ly-6C antigen, mouseNerve Growth FactorsNeuropeptidesPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Vasoactive Intestinal Peptide, Type IIReceptors, Vasoactive Intestinal Polypeptide, Type Iacute infectioninnate immunitymacrophagesmonocytesneurotrophinspituitary adenylate cyclase-activating polypeptide (PACAP)Toxoplasma gondii

Identifiers

PMID31192159
PMCPMC6546896
OpenAlexW2947770459

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.