ArticleGlobal spine journal2019
Hypoalbuminemia as an Independent Risk Factor for Perioperative Complications Following Surgical Decompression of Spinal Metastases.
Article in Global spine journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Association between malnutrition and surgical site wound infection among spinal surgery patients: A meta-analysis.International wound journal · 2023Pooled it
- Beyond albumin: a systematic review, meta-analysis, and GRADE assessment of seven preoperative nutritional and inflammatory biomarkers in metastatic spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Preoperative hypoalbuminemia predicts early complications, mortality, and discharge disposition following surgical resection of spinal metastases: a nationwide study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Preoperative geriatric nutritional risk index is a reliable tool for predicting postoperative adjacent segment disease among elderly patients with degenerative lumbar diseases: a case control study.BMC musculoskeletal disorders · 2026Article
- Prognostic Significance of Preoperative Albumin and Prealbumin in Predicting Adverse Events After Posterior Lumbar Interbody Fusion in Elderly Patients.Clinical interventions in aging · 2026Article
- Prognostic nutritional index versus pragmatically operationalized GLIM criteria for predicting postoperative complications and recovery in spine surgery: a prospective cohort study.Frontiers in nutrition · 2026Article
- Serum Albumin Level as a Predictor of Failure to Rescue in Patients Undergoing Surgery for Spinal Metastases.Cancers · 2025Article
- Assessing combined effects of risk analysis index-revised (RAI-rev), malnutrition, and anemia on morbidity and mortality after spine surgery for metastatic spinal tumors.Journal of neuro-oncology · 2025Article
- Article
- The utilization of hypoalbuminemia as a prognostic metric in patients with spinal metastases: A scoping review.Brain & spine · 2025Review
- Malnutrition in Spine Oncology: Where Are We and What Are We Measuring?Global spine journal · 2025Article
- Association of Malnutrition with Surgical and Hospital Outcomes after Spine Surgery for Spinal Metastases: A National Surgical Quality Improvement Program Study of 1613 Patients.Journal of clinical medicine · 2024Article
- Article
- Use of the Geriatric Nutritional Risk Index to Assess Risk for Postoperative Complications Following Posterior Cervical Decompression/Fusion.International journal of spine surgery · 2023Article
- Racial Disparities in Perioperative Morbidity Following Oncological Spine Surgery.Global spine journal · 2023Article
- Performance assessment and external validation of specific thresholds of total psoas muscle cross-sectional area as predictors of mortality in oncologic spine surgery for spinal metastases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Hypoalbuminemia and Elevated CRP are Risk Factors for Deep Infections and Urinary Tract Infections After Lumbar Spine Surgery in a Large Retrospective Patient Population.Global spine journal · 2023Article
- The predictive ability of routinely collected laboratory markers for surgically treated spinal metastases: a retrospective single institution study.BMC cancer · 2022Article
- Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review.The Lancet. Oncology · 2022Article
- Association between preoperative serum albumin and prognosis in patients with adrenocortical carcinoma after primary resection: a retrospective study.BMC cancer · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRetrospective cohort study.
objectiveMalnutrition has been shown to be a risk factor for poor perioperative outcomes in multiple surgical subspecialties, but few studies have specifically investigated the effect of hypoalbuminemia in patients undergoing operative treatment of metastatic spinal tumors. The aim of this study was to assess the role of hypoalbuminemia as an independent risk factor for 30-day perioperative mortality and morbidity after surgical decompression of metastatic spinal tumors using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2011 to 2014.
methodsWe identified 1498 adult patients in the ACS-NSQIP database who underwent laminectomy and excision of metastatic extradural spinal tumors. Patients were categorized into normoalbuminemic and hypoalbuminemic (ie, albumin level <3.5 g/dL) groups. Univariate and multivariate regression analyses were performed to examine the association between preoperative hypoalbuminemia and 30-day perioperative mortality and morbidity. Subgroup analysis was performed in the hypoalbuminemic group to assess the dose-dependent effect of albumin depletion.
resultsHypoalbuminemia was associated with increased risk of perioperative mortality, any complication, sepsis, intra- or postoperative transfusion, prolonged hospitalization, and non-home discharge. However, albumin depletion was also associated with decreased risk of readmission. There was an albumin level-dependent effect of increasing mortality and complication rates with worsening albumin depletion.
conclusionsHypoalbuminemia is an independent risk factor for perioperative mortality and morbidity following surgical decompression of metastatic spinal tumors with a dose-dependent effect on mortality and complication rates. Therefore, it is important to address malnutrition and optimize nutritional status prior to surgery.
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