Evidence map›Paper›PMID 31192031›Full record

ArticleJournal of clinical & experimental ophthalmology2019

Mitochondrial haplogroup L1c2 is associated with increased disease severity in African American patients with primary open-angle glaucoma.

Qi N Cui, Meera S Ramakrishnan, Harini V Gudiseva, David W Collins, Maxwell Pistilli, Roy Lee, Venkata M Chavali, Amanda Lehman, Victoria M Addis, Joan M O'Brien

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & experimental ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Association between ActiveMicroorganisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Qi N CuiScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Meera S RamakrishnanScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Harini V GudisevaScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
David W CollinsScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Maxwell PistilliScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Roy LeeScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Venkata M ChavaliScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Amanda LehmanScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Victoria M AddisScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Joan M O'BrienScheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Penn Presbyterian Medical Center · USUniversity of Pennsylvania · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Primary Open Angle African-American Glaucoma Genetics Study RenewalR01EY023557 · NEI · UNIVERSITY OF PENNSYLVANIA · PI O'BRIEN, JOAN M · 2014 to 2025
$18.1M
PENN Vision Clinical Scientist ProgramK12EY015398 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2004 to 2026
$11.7M
Mitochondrial Respiratory Chain Dysfunction in Primary Open Angle GlaucomaK08EY029765 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CUI, QI N · 2019 to 2021
$731k
NEI NIH HHS HHSN263201200001CNEI NIH HHS K08 EY029765NEI NIH HHS K12 EY015398NEI NIH HHS L30 EY029353NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY023557NIH HHS HHSN263201200001E
6 · The paper itself

Abstract

objectiveThe purpose of this study is to evaluate the role mitochondrial inheritance plays in primary open-angle glaucoma (POAG) characteristics in African Americans.

methodsPOAG cases from the L1c2 and L1b mitochondrial haplogroups were compared in a retrospective case-case study. Twenty-six pairs of self-identified African American POAG cases from L1c2 and L1b mitochondrial haplogroups matched on age (mean [SD] = 71.2 [9.6] and 71.3 [9.6] years, respectively;

resultsL1c2 subjects displayed higher vertical cup-to-disc ratio (0.75 [0.12] and 0.67 [0.16], respectively;

conclusionResults demonstrated worse glaucomatous cupping and more severe VF loss in the L1c2 compared to the L1b haplogroup despite comparable IOP. Findings implicate mitochondrial inheritance as a factor affecting POAG severity and may ultimately contribute to stratifying POAG patients into phenotypically and genotypically distinct subgroups.

Indexed as

African AmericansGlaucomamitochondrial geneticsmitochondrial haplogroupsPrimary open-angle glaucoma

Identifiers

PMID31192031
PMCPMC6561505
OpenAlexW3012001555

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.