ReviewEFORT open reviews2019
The role of orthopaedic surgery in haemophilia: current rationale, indications and results.
Review in EFORT open reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Surgical management of supracondylar humerus fracture in a child with severe hemophilia A: A case report.Trauma case reports · 2026Article
- Article
- Disease burden and unmet medical need in severe hemophilia in Greece: insights from clinicians and patients.Frontiers in public health · 2026Article
- Bio-hybrid scaffolds combining polyvinyl alcohol and decellularized articular cartilage for the treatment of focal chondral lesions in hemophilic patients.Frontiers in pharmacology · 2025Article
- Shoulder Arthroplasty in Hemophilia.The archives of bone and joint surgery · 2025Article
- Emergency-Driven Multiple Simultaneous Invasive Procedures in Haemophilia.Life (Basel, Switzerland) · 2024Article
- Anesthetic considerations for joint replacement surgery in hemophilic arthropathy: a comprehensive review.Anesthesia and pain medicine · 2024Review
- Physical therapy for end-stage hemophilic arthropathy: a case report.BMC musculoskeletal disorders · 2023Article
- Short-term Effectiveness of a Modified Osteotomy for Total Elbow Joint Replacement in Patients of Hemophilic Elbow Arthritis with Severe Flexion Contracture Deformity: A Three-Cases Series Report.Orthopaedic surgery · 2022Article
- Managing surgery in hemophilia with recombinant factor VIII Fc and factor IX Fc: Data on safety and effectiveness from phase 3 pivotal studies.Research and practice in thrombosis and haemostasis · 2022Article
- Current and Emerging Approaches for Pain Management in Hemophilic Arthropathy.Pain and therapy · 2022Review
- How to manage bleeding disorders in aging patients needing surgery.Hematology. American Society of Hematology. Education Program · 2021Article
- Haemophilia.Nature reviews. Disease primers · 2021Review
- Current practices in haemophilic patients undergoing orthopedic surgery - a systematic review.Experimental and therapeutic medicine · 2020Article
- Total Knee Arthroplasty in Patients with Hemophilia: What Do We Know?The archives of bone and joint surgery · 2020Review
- Musculo-skeletal problems of the hand in haemophilia.EFORT open reviews · 2020Review
- Hemophilic Pseudotumors: Diagnosis and Management.The archives of bone and joint surgery · 2020Review
- Total Ankle Replacement in Hemophilia.Cardiovascular & hematological disorders drug targets · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The musculoskeletal problems of haemophilic patients begin in infancy when minor injuries lead to haemarthroses and haematomas.Early continuous haematological primary prophylaxis by means of the intravenous infusion of the deficient coagulation factor (ideally from cradle to grave) is of paramount importance because the immature skeleton is very sensitive to the complications of haemophilia: severe structural deficiencies may develop quickly.If primary haematological prophylaxis is not feasible due to expense or lack of venous access, joint bleeding will occur. Then, the orthopaedic surgeon must aggressively treat haemarthrosis (joint aspiration under factor coverage) to prevent progression to synovitis (that will require early radiosynovectomy or arthroscopic synovectomy), recurrent joint bleeds, and ultimately end-stage osteoarthritis (haemophilic arthropathy).Between the second and fourth decades, many haemophilic patients develop articular destruction. At this stage the main possible treatments include arthroscopic joint debridement (knee, ankle), articular fusion (ankle) and total joint arthroplasty (knee, hip, ankle, elbow). Cite this article:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.