Evidence map›Paper›PMID 31191914›Full record

ArticleJournal of virus eradication2019

What risk of death would people take to be cured of HIV and why? A survey of people living with HIV.

Benjamin R Murray, Allison Kratka, Karen A Scherr, Nir Eyal, Jennifer Blumenthal-Barby, Kenneth A Freedberg, Daniel R Kuritzkes, James K Hammitt, Regina Edifor, Madelaine N Katz and 5 more

Open access · goldAbstract readEditorial
In one paragraph

Article in Journal of virus eradication, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Benjamin R MurrayDuke University School of Medicine, Durham, NC, USA.
Allison KratkaDuke University School of Medicine, Durham, NC, USA.
Karen A ScherrDuke University School of Medicine, Durham, NC, USA.
Nir EyalHarvard TH Chan School of Public Health, Boston, MA, USA.
Jennifer Blumenthal-BarbyBaylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, TX, USA.
Kenneth A FreedbergHarvard TH Chan School of Public Health, Boston, MA, USA.
Daniel R KuritzkesHarvard Medical School, Boston, MA, USA.
James K HammittHarvard TH Chan School of Public Health, Boston, MA, USA.
Regina EdiforUniversity of Massachusetts Medical School, Worcester, MA, USA.
Madelaine N KatzDuke University Fuqua School of Business, Durham, NC, USA.
Kathryn I PollakDuke University School of Medicine, Durham, NC, USA.
Brian J Zikmund-FisherDepartment of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Scott D HalpernDepartments of Medicine and Medical Ethics in Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mary C BarksDuke University Fuqua School of Business, Durham, NC, USA.
Peter A UbelDuke University School of Medicine, Durham, NC, USA.
Duke University · USHarvard University · USBaylor College of Medicine · USToulouse School of Economics · FRUniversity of Massachusetts Chan Medical School · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · US

Funding

HIV cure studies: risk, risk perception, and ethicsR56AI114617 · NIAID · HARVARD MEDICAL SCHOOL · PI EYAL, NIR · 2014 to 2014
$528k
NIAID NIH HHS R56 AI114617
6 · The paper itself

Abstract

People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between the benefits they anticipate from a cure and their risk tolerance for curative treatments. Sixty-five per cent expected their health to improve if cured of HIV, 41% predicted the virus would stop responding to medications over the next 20 years and 54% predicted experiencing serious medication side effects in the next 20 years. Respondents' willingness to risk death for a cure varied widely (median 10%, 75th percentile 50%). In multivariate analyses, willingness to risk death was associated with expected long-term side effects of ART, greater financial resources and being employed (all

Indexed as

HIVmedicationrisk takingtreatment

Identifiers

PMID31191914
PMCPMC6543487
OpenAlexW2984167108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.