Evidence map›Paper›PMID 31191872›Full record

ArticleMedChemComm2019

Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1.

Benjamin C Giglio, Hui Wang, Xuefeng Yan, Zibo Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Development of [Journal of medicinal chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benjamin C GiglioDepartment of Radiology and Biomedical Research Imaging Center , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , USA . Email: ziboli@med.unc.edu.
Hui WangDepartment of Radiology and Biomedical Research Imaging Center , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , USA . Email: ziboli@med.unc.edu.
Xuefeng YanDepartment of Radiology and Biomedical Research Imaging Center , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , USA . Email: ziboli@med.unc.edu.ORCID 0000-0002-9803-5222
Zibo LiDepartment of Radiology and Biomedical Research Imaging Center , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , USA . Email: ziboli@med.unc.edu.ORCID 0000-0002-5095-3761
University of North Carolina at Chapel Hill · US

Funding

Development of IDO PET agents for immunotherapyR01CA233904 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, MOSCHOS, STERGIOS · 2019 to 2023
$2.0M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
NCI NIH HHS R01 CA233904NIH HHS S10 OD023611
6 · The paper itself

Abstract

A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). An enzyme based assay demonstrated that 5-I-AMT is a substrate of IDO-1. The

Identifiers

PMID31191872
PMCPMC6540958
OpenAlexW2936586466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.