Evidence map›Paper›PMID 31191870›Full record

ArticleMedChemComm2019

Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (-)-zampanolide and (-)-dactylolide.

Jeffrey L Henry, Matthew R Wilson, Michael P Mulligan, Taylor R Quinn, Dan L Sackett, Richard E Taylor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeffrey L HenryThe Warren Family Research Center for Drug Discovery and Development and the Department of Chemistry & Biochemistry , University of Notre Dame , Notre Dame , IN 46556-5670 , USA . Email: rtaylor@nd.edu.
Matthew R WilsonVertex Pharmaceuticals , 50 Northern Ave , Boston , MA 02210 , USA.
Michael P MulliganThe Warren Family Research Center for Drug Discovery and Development and the Department of Chemistry & Biochemistry , University of Notre Dame , Notre Dame , IN 46556-5670 , USA . Email: rtaylor@nd.edu.
Taylor R QuinnThe Warren Family Research Center for Drug Discovery and Development and the Department of Chemistry & Biochemistry , University of Notre Dame , Notre Dame , IN 46556-5670 , USA . Email: rtaylor@nd.edu.
Dan L SackettEunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health , Bethesda , MD 20892 , USA.
Richard E TaylorThe Warren Family Research Center for Drug Discovery and Development and the Department of Chemistry & Biochemistry , University of Notre Dame , Notre Dame , IN 46556-5670 , USA . Email: rtaylor@nd.edu.ORCID 0000-0003-1146-7493

Funding

Microtubule regulation by small molecules.ZIAHD008765 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SACKETT, DAN L · 2009 to 2025
$8.9M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
Synthesis and Biosynthesis of Pyran and Spiroketal Structural UnitsR01GM084922 · NIGMS · UNIVERSITY OF NOTRE DAME · PI TAYLOR, RICHARD E. · 2010 to 2013
$1.1M
NIGMS NIH HHS R01 GM084922NIGMS NIH HHS T32 GM075762
6 · The paper itself

Abstract

Zampanolide and dactylolide are microtubule-stabilizing polyketides possessing potent cytotoxicity towards a variety of cancer cell lines. Using our understanding of the conformational preferences of the macrolide core in both natural products, we hypothesized that analogues lacking the C17-methyl group would maintain the necessary conformation for bioactivity while reducing the number of synthetic manipulations necessary for their synthesis. Analogues

Identifiers

PMID31191870
PMCPMC6540953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.