ReviewPain research & management2019
Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People.
Review in Pain research & management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.Nature reviews. Rheumatology · 2020Pooled it
- A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine.Frontiers in psychiatry · 2020Pooled it
- Associations between PTSD symptom clusters and multi-region pain in young adults with chronic pain.Journal of behavioral medicine · 2026Article
- Pain as Lived Experience: Philosophical Perspectives in Pain Medicine - A Narrative Review.Journal of pain research · 2026Review
- Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain.Pain · 2025Article
- Associations Between Lifetime Histories of Iron Deficiency, Anxiety, Depression and Multiple Pain Conditions: An Observational Study Using a Large-Scale National Database.Journal of pain research · 2025Article
- Trauma-Based Sexually Dimorphic Changes in the Connectome and Its Association with Central Sensitization Syndromes-A Systematic Review.Brain sciences · 2024Review
- Early-life adversity predicting the incidence of multisite chronic pain in the general population.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Chronic widespread pain and cause of death: a 25-year follow-up study.Pain reports · 2024Article
- Review
- The relationship between lifecourse traumatic events and pain in an older rural South African population: A cross-sectional study.PloS one · 2024Article
- REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia.Journal of personalized medicine · 2023Article
- Predicting the Need for Transition from Pediatric to Adult Pain Services: A Retrospective, Longitudinal Study Using the Electronic Persistent Pain Outcome Collaboration (ePPOC) Databases.Children (Basel, Switzerland) · 2023Article
- Online Questionnaire with Fibromyalgia Patients Reveals Correlations among Type of Pain, Psychological Alterations, and Effectiveness of Non-Pharmacological Therapies.Healthcare (Basel, Switzerland) · 2022Article
- VOSviewer-Based Bibliometric Network Analysis for Evaluating Research on Juvenile Primary Fibromyalgia Syndrome (JPFS).Children (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the life-course concept of risk markers as potential etiological influences is well established in epidemiology, it has not featured in academic publications or clinical practice in the context of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Studies of risk markers are required considerations for evaluation of patients and for research because there is no single cause, pathological feature, laboratory finding, or biomarker for CWP or FMS. The early-life risk markers identified by extensive literature review with best evidence for potential causal influence on the development and progression of CWP and FMS include genetic factors, premature birth, female sex, early childhood adversity, cognitive and psychosocial influences, impaired sleep, primary pain disorders, multiregional pain, physical trauma, infectious illness, obesity and inactivity, hypermobility of joints, iron deficiency, and small-fiber polyneuropathy. The case history illustrates the potential etiological influence of multiple risk markers offset by personal resilience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.