ArticleDisease markers2019
Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients.
Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Prognostic utility of serum 25-hydroxyvitamin D in patients with stroke: a meta-analysis.Journal of neurology · 2020Pooled it
- Vitamin D and Stroke: Effects on Incidence, Severity, and Outcome and the Potential Benefits of Supplementation.Frontiers in neurology · 2020Pooled it
- Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES.Nutrition journal · 2025Article
- Vitamin D deficiency and risk of acute kidney injury after ischemic stroke: a propensity-matched cohort study.Frontiers in nutrition · 2025Article
- Role of vitamin D in the association between pre-stroke sleep quality and poststroke depression and anxiety.Sleep & breathing = Schlaf & Atmung · 2024Article
- Selected serum cytokines and vitamin D levels as potential prognostic markers of acute ischemic stroke.PloS one · 2024Article
- Association between Vitamin D and Short-Term Functional Outcomes in Acute Ischemic Stroke.Nutrients · 2023Article
- Novel Insights into the Molecular Mechanisms of Atherosclerosis.International journal of molecular sciences · 2023Review
- Association of Long Non-Coding RNA Malat1 with Serum Levels of Interleukin-1 Beta and Vitamin D in Patients with Ischemic Stroke.Galen medical journal · 2023Article
- Vitamin D3 and Ischemic Stroke: A Narrative Review.Antioxidants (Basel, Switzerland) · 2022Review
- Genetically-Proxied Levels of Vitamin D and Risk of Intracerebral Hemorrhage.Journal of the American Heart Association · 2022Article
- The Role of Vitamin D in Stroke Prevention and the Effects of Its Supplementation for Post-Stroke Rehabilitation: A Narrative Review.Nutrients · 2022Review
- Vitamin D: The silent rescuer from ischemic stroke.Annals of medicine and surgery (2012) · 2022Article
- Vitamin D serum level predicts stroke clinical severity, functional independence, and disability-A retrospective cohort study.Frontiers in neuroscience · 2022Article
- The Evaluation of the Neuroprotective Effect of a Single High-Dose Vitamin DStroke research and treatment · 2022Article
- Low vitamin D levels and the long-term functional outcome of stroke up to 5 years.Brain and behavior · 2021Article
- Double-Edged Sword of Vitamin D3 Effects on Primary Neuronal Cultures in Hypoxic States.International journal of molecular sciences · 2021Article
- Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis.Biomedicines · 2021Review
- Does vitamin D administration play a role in outcome of patients with acute ischemic stroke? A randomized controlled trial.Current journal of neurology · 2021Article
- Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway.Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS). We assessed the hypothesis that decreased levels of 25-hydroxyvitamin D (25-OH-D) are associated with increased risk of mortality in patients with IS.
methodsSerum 25-OH-D, intact parathyroid hormone (iPTH), and intact fibroblast growth factor 23 (iFGF23) levels were assessed in serum of 240 consecutive patients admitted within the 24 hours after the onset of IS. Mortality data was obtained from the local registry office.
resultsOnly three subjects (1.3%) had an optimal 25-OH-D level (30-80 ng/mL), 25 (10.4%) had a mildly reduced (insufficient) level, 61 (25.4%) had moderate deficiency, and 151 (62.9%) had a severe VD deficiency. 20% subjects had secondary hyperparathyroidism. The serum 25-OH-D level was significantly lower than that in 480 matched subjects (9.9 ± 7.1 vs. 21.0 ± 8.7 ng/mL). Of all the patients, 79 (32.9%) died during follow-up observation (44.9 months). The mortality rates (per year) were 4.81 and 1.89 in a group with and without severe VD deficiency, respectively (incidence rate ratio: 2.52; 95% CI: 1.44-4.68). There was no effect of secondary hyperparathyroidism and iFGF23 levels on mortality rates. Age, 25 - OH - D < 10 ng/mL, and functional status (modified Rankin scale) were significant factors increasing the risk of death in multivariable Cox proportional hazard regression test.
conclusionsSevere VD deficiency is an emerging, strong negative predictor for survival after IS, independent of age and functional status. VD supplementation in IS survivals may be considered due to high prevalence of its deficiency. However, it is uncertain whether it will improve their survival.
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