Evidence map›Paper›PMID 31191748›Full record

ArticleDisease markers2019

Investigating the Protein Signature of Adamantinomatous Craniopharyngioma Pediatric Brain Tumor Tissue: Towards the Comprehension of Its Aggressive Behavior.

Claudia Martelli, Riccardo Serra, Ilaria Inserra, Diana Valeria Rossetti, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Andrea Urbani, Gianpiero Tamburrini, Massimo Caldarelli and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pediatric Brain Tumors: Signatures from the Intact Proteome.International journal of molecular sciences · 2022
    Article
  7. Treatment of Cystic Craniopharyngiomas: An Update.Advances and technical standards in neurosurgery · 2022
    Article
  8. Article
  9. Adamantinomatous craniopharyngioma: advances in proteomic research.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Review
  10. Antimicrobial effects of craniopharyngioma cystic fluid.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Article
  11. Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Claudia MartelliIstituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy.
Riccardo SerraUniversità Cattolica del Sacro Cuore, Istituto di Neurochirurgia, Roma, Italy.
Ilaria InserraIstituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy.
Diana Valeria RossettiIstituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy.
Federica IavaroneIstituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy.
Federica VincenzoniIstituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy.
Massimo CastagnolaIstituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Roma, Italy.
Andrea UrbaniIstituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italy.
Gianpiero TamburriniUniversità Cattolica del Sacro Cuore, Istituto di Neurochirurgia, Roma, Italy.
Massimo CaldarelliUniversità Cattolica del Sacro Cuore, Istituto di Neurochirurgia, Roma, Italy.
Luca MassimiUniversità Cattolica del Sacro Cuore, Istituto di Neurochirurgia, Roma, Italy.
Claudia DesiderioIstituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Roma, Italy.ORCID 0000-0003-0784-3599
Università Cattolica del Sacro Cuore · ITInstitute of Chemistry of Molecular Recognition · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although histologically benign, adamantinomatous craniopharyngioma (AC) pediatric brain tumor is a locally aggressive disease that frequently determines symptoms and hormonal dysfunctions related to the mass effect on the surrounding structures. Another typical feature of this benign neoplasm is the presence of voluminous liquid cysts frequently associated with the solid component. Even if studies have been devoted to the proteomic characterization of the tumor intracystic fluid, poor explorations have been performed on its solid part, principally investigated by transcriptomics technologies. In the present study, seven specimens of AC whole tumor tissue have been analyzed by LC-MS for a preliminary assessment of the proteomic profile by a top-down/bottom-up integrated approach. Thymosin beta 4, ubiquitin, calmodulin, S100 proteins, prothymosin

Indexed as

AdolescentBiomarkers, TumorBrainBrain NeoplasmsChildCraniopharyngiomaFemaleHumansMaleProteomeBiomarkers, TumorProteome

Identifiers

PMID31191748
PMCPMC6525946
OpenAlexW2942800128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.