Evidence map›Paper›PMID 31191653›Full record

ArticleJournal of oncology2019

MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels.

Jarline Encarnación-Medina, Carmen Ortiz, Ralphdy Vergne, Luis Padilla, Jaime Matta

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jarline Encarnación-MedinaBasic Sciences Department, Division of Pharmacology & Toxicology and Cancer Biology, Ponce Research Institute, Ponce 00716-2348, PR, USA.ORCID 0000-0002-0354-6274
Carmen OrtizBasic Sciences Department, Division of Pharmacology & Toxicology and Cancer Biology, Ponce Research Institute, Ponce 00716-2348, PR, USA.ORCID 0000-0003-3567-7866
Ralphdy VergneBiology Department, University of Puerto Rico at Ponce, Ponce 00716-9996, PR, USA.
Luis PadillaBiology Department, University of Puerto Rico at Ponce, Ponce 00716-9996, PR, USA.
Jaime MattaBasic Sciences Department, Division of Pharmacology & Toxicology and Cancer Biology, Ponce Research Institute, Ponce 00716-2348, PR, USA.
Ponce Health Sciences University · PRUniversity of Puerto Rico at Ponce · PR

Funding

Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Harold I Saavedra · 2012 to 2026
$23.0M
Therapeutic Immunization in Monkey Model of AIDSS06GM008239 · NIGMS · PONCE SCHOOL OF MEDICINE · PI MATTA, JAIME L · 1989 to 2009
$21.5M
UNIVERSITY OF PUERTO RICO PONCE RESEARCH INITIATIVE FOR SCIENTIFIC ENHANCEMENT: UR25GM096955 · NIGMS · UNIVERSITY OF PUERTO RICO PONCE · PI SUAREZ-MARTINEZ, EDU B · 2011 to 2020
$5.7M
Factors associated with variability in DNA repair capacity in their effect on breSC1CA182846 · NCI · PONCE SCHOOL OF MEDICINE · PI MATTA, JAIME L · 2013 to 2016
$1.5M
Molecular epidemiology studies on the role of DNA repair breast cancerSC1CA157250 · NCI · PONCE SCHOOL OF MEDICINE · PI MATTA, JAIME L · 2010 to 2012
$1.0M
NCI NIH HHS SC1 CA157250NCI NIH HHS SC1 CA182846NCI NIH HHS U54 CA163071NIGMS NIH HHS R25 GM096955NIGMS NIH HHS S06 GM008239
6 · The paper itself

Abstract

Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide and is the leading cause of death among Hispanic women. Previous studies have shown that women with a low DNA repair capacity (DRC), measured through the nucleotide excision repair (NER) pathway, have an increased BC risk. Moreover, we previously reported an association between DRC levels and the expression of the microRNA (miRNA) let-7b in BC patients. MiRNAs can induce genomic instability by affecting the cell's DNA damage response while influencing the cancer pathobiology. The aim of this pilot study is to identify plasma miRNAs related to variations in DRC levels in BC cases.

Identifiers

PMID31191653
PMCPMC6525916
OpenAlexW2944088207

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.