Evidence map›Paper›PMID 31191552›Full record

ArticleFrontiers in immunology2019

Novel Targeting to XCR1

Yusuke Kitazawa, Hisashi Ueta, Yasushi Sawanobori, Tomoya Katakai, Hiroyuki Yoneyama, Satoshi Ueha, Kouji Matsushima, Nobuko Tokuda, Kenjiro Matsuno

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yusuke KitazawaDepartment of Anatomy (Macro), School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Hisashi UetaDepartment of Anatomy (Macro), School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Yasushi SawanoboriDepartment of Anatomy (Macro), School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Tomoya KatakaiDepartment of Immunology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Hiroyuki YoneyamaTME Therapeutics Inc., Tokyo, Japan.
Satoshi UehaDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
Kouji MatsushimaDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
Nobuko TokudaDepartment of Anatomy (Macro), School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Kenjiro MatsunoDepartment of Anatomy (Macro), School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Dokkyo Medical University · JPTokyo University of Science · JPNiigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination strategy that induce efficient antibody responses polytopically in most lymph nodes (LNs) against infections has not been established yet. Because donor-specific blood transfusion induces anti-donor class I MHC antibody production in splenectomized rats, we examined the mechanism and significance of this response. Among the donor blood components, T cells were the most efficient immunogens, inducing recipient T cell and B cell proliferative responses not only in the spleen, but also in the peripheral and gut LNs. Donor T cells soon migrated to the splenic T cell area and the LNs, with a temporary significant increase in recipient NK cells. XCR1

Indexed as

AnimalsBlood DonorsBlood TransfusionCell MovementDendritic CellsEpitopesG(M1) GangliosideHistocompatibility Antigens Class IIsoantibodiesKiller Cells, NaturalLymph NodesLymphocyte ActivationLymphocyte TransfusionPertussis ToxinPeyer's PatchesPhagocytosisasialo GM1 gangliosideEpitopesG(M1) GangliosideHistocompatibility Antigens Class IIsoantibodiesPertussis ToxinReceptors, G-Protein-CoupledXCR1 protein, humanallogeneic T cellaspleniadendritic cell targetinglymph nodespolytopical antibody productionvaccinationXCR1+ dendritic cell

Identifiers

PMID31191552
PMCPMC6548820
OpenAlexW2947974914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.