Evidence map›Paper›PMID 31191527›Full record

ArticleFrontiers in immunology2019

A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation.

Carla Guenther, Imrul Faisal, Liisa M Uotila, Marc Llort Asens, Heidi Harjunpää, Terhi Savinko, Tiina Öhman, Sean Yao, Markus Moser, Stephan W Morris and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  3. Focus on mechano-immunology: new direction in cancer treatment.International journal of surgery (London, England) · 2025
    Review
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Tuning immunity through tissue mechanotransduction.Nature reviews. Immunology · 2023
    Review
  12. Actin dynamics in protein homeostasis.Bioscience reports · 2022
    Review
  13. Article
  14. Expression of the phagocytic receptors αFrontiers in immunology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. The Human Tissue-Engineered Cornea (hTEC): Recent Progress.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Carla GuentherFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
Imrul FaisalFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
Liisa M UotilaFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
Marc Llort AsensFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
Heidi HarjunpääFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
Terhi SavinkoFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
Tiina ÖhmanInstitute of Biotechnology, University of Helsinki, Helsinki, Finland.
Sean YaoDepartment of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Markus MoserDepartment of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.
Stephan W MorrisDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Sari TojkanderInstitute of Biotechnology, University of Helsinki, Helsinki, Finland.
Susanna Carola FagerholmFagerholm Lab, MIBS, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIMax Planck Institute of Biochemistry · DESt. Jude Children's Research Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β2-integrins are essential for immune system function because they mediate immune cell adhesion and signaling. Consequently, a loss of β

Indexed as

AnimalsBiomechanical PhenomenaCD18 AntigensCell AdhesionCell MovementCells, CulturedCytoskeletal ProteinsDendritic CellsGene Expression ProfilingGene OntologyGene Regulatory NetworksMice, Inbred C57BLMice, KnockoutMice, TransgenicrhoA GTP-Binding ProteinSerum Response FactorCD18 AntigensCytoskeletal Proteinskindlin-3 protein, mouseMrtfa protein, mouserhoA GTP-Binding ProteinSerum Response FactorSrf protein, mouseTrans-Activatorsadhesiondendritic cellsLAD-IIIMKL-1MRTF-ASRFtraction force

Identifiers

PMID31191527
PMCPMC6546827
OpenAlexW2947069836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.