Evidence map›Paper›PMID 31191366›Full record

ArticleFrontiers in physiology2019

Myokine/Adipokine Response to "Aerobic" Exercise: Is It Just a Matter of Exercise Load?

Zihong He, Ye Tian, Pedro L Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Genes · 2025
    Trial
  5. Trial
  6. Article
  7. Review
  8. Exercise, Exerkines, and Sarcopenia.Diabetes & metabolism journal · 2026
    Review
  9. Article
  10. Exerkine response to acute exercise: Still much to discover.Journal of sport and health science · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Zihong HeBiology Center, China Institute of Sport Science, Beijing, China.
Ye TianCulture Development Center, General Administration of Sport of China, Beijing, China.
Pedro L ValenzuelaPhysiology Unit, Department of Systems Biology, University of Alcalá, Madrid, Spain.
Chuanye HuangGraduate School, Shandong Sport University, Jinan, China.
Jiexiu ZhaoBiology Center, China Institute of Sport Science, Beijing, China.
Ping HongWinter Sports Administrative Center, General Administration of Sport of China, Beijing, China.
Zilin HeCardiovascular Department, Beijing Jian Gong Hospital, Beijing, China.
Shuhui YinThe Rocket Force General Hospital of PLA, Institute of Hepatobiliary Gastrointestinal Disease, Beijing, China.
Alejandro LuciaFaculty of Sport Sciences, European University of Madrid, Madrid, Spain.
China Institute of Sport Science · CNGeneral Administration of Sport of China · CNAir Force General Hospital PLA · CNResearch Institute Hospital 12 de Octubre · ESShandong Sport University · CNUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExercise health benefits are partly mediated by exertional changes in several myokines/adipokines. This study aimed to compare the acute response of some of these biomarkers to aerobic exercise performed at the intensity corresponding to the maximum fat oxidation rate (FATmax) or the "anaerobic" threshold (AT).

methodsFollowing a cross-over, counterbalanced design, 14 healthy untrained men (23 ± 1 years) performed a 45-min exercise bout at their FATmax or AT intensity (been previously determined through incremental exercise tests). The concentration of interleukin (IL)-15, follistatin, myostatin, fibroblast-growth factor (FGF)-21, irisin, resistin, and omentin was measured at baseline and 0, 1, 3, 24, 48, and 72 h post-exercise.

resultsAT exercise was performed at a higher intensity (85 ± 8 vs. 52 ± 14% of maximal oxygen uptake [VO

conclusionIncreasing exercise load (from FATmax to AT) results in a higher response of FGF-21, follistatin and omentin to aerobic exercise, with the subsequent potential cardiometabolic benefits. No effects were, however, observed on the remainder of biomarkers. Future research should address if manipulating other exercise variables (e.g., type, frequency) can promote a higher myokine/adipokine response.

Indexed as

cytokinesmetabolismphysical activityresponderstraining

Identifiers

PMID31191366
PMCPMC6549222
OpenAlexW2947053774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.