Evidence map›Paper›PMID 31191341›Full record

ArticleFrontiers in physiology2019

Efficacy of an All-Natural Polyherbal Mouthwash in Patients With Periodontitis: A Single-Blind Randomized Controlled Trial.

Scilla Sparabombe, Riccardo Monterubbianesi, Vincenzo Tosco, Giulia Orilisi, Andrell Hosein, Luigi Ferrante, Angelo Putignano, Giovanna Orsini

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07402694 (Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07402694 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy

TypeinterventionalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2026 to 2027Enrolled60ConditionsPeriodontitis, MouthwashArmsAmphion® Mouthwash, Placebo Mouthwash
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Review
  12. Effect of the DarolacMicroorganisms · 2025
    Review
  13. Novel Mouth Rinse Displaying Analgesic and Anti-inflammatory Properties: AnAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2025
    Article
  14. Review
  15. Review
  16. Effectiveness of propolis in maintaining oral health: a scoping review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scilla SparabombeDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, Italy.
Riccardo MonterubbianesiDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, Italy.
Vincenzo ToscoDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, Italy.
Giulia OrilisiDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, Italy.
Andrell HoseinDepartment of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
Luigi FerranteDepartment of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy.
Angelo PutignanoDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, Italy.
Giovanna OrsiniDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

all-natural polyherbalclinical attachment levelfull mouth bleeding scorefull mouth plaque scoremouthwashperiodontitisprobing depthrandomized controlled trial

Identifiers

PMID31191341
PMCPMC6540781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.