ArticleFrontiers in pharmacology2019
The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion.
Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522179 (Nutritional Supplements to Support Recovery After Foot Surgery - A Pilot Study), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Supplements to Support Recovery After Foot Surgery - A Pilot Study
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Vitamin D Status and Supplementation in Lumbar Spinal Fusion: A Systematic Review and Meta-Analysis of Radiographic and Clinical Outcomes.Journal of musculoskeletal & neuronal interactions · 2026Pooled it
- Pooled it
- Role of vitamin D supplementation in modifying outcomes after surgery: a systematic review of randomised controlled trials.BMJ open · 2024Pooled it
- Pre-admission interventions (prehabilitation) to improve outcome after major elective surgery: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- Effect of 12-Week BMI-Based Vitamin DInternational journal of molecular sciences · 2023Trial
- Trial
- Prehabilitation in Obese Patients with Ventral Hernia: A Narrative Review and Proposal of a Clinical Algorithm.Journal of clinical medicine · 2026Review
- Preoperative vitamin D insufficiency increases the risk of delayed neurocognitive recovery via acute systemic inflammation in elderly women undergoing gynecological surgery.Frontiers in medicine · 2026Article
- Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management.Global spine journal · 2025Article
- 1,25(OH)₂D₃ inhibits ferroptosis in nucleus pulposus cells via VDR signaling to mitigate lumbar intervertebral disc degeneration.Scientific reports · 2025Article
- Bone Health Optimization in Adult Spinal Deformity Patients: A Narrative Review.Journal of clinical medicine · 2024Review
- Effects of Probiotics and Vitamin DSports medicine - open · 2023Article
- Development and Validation of a Predictive Model for Chronic Postsurgical Pain After Arthroscopic Rotator Cuff Repair: A Prospective Cohort Study.Journal of pain research · 2023Article
- A comparative study on efficacies of posterior microscopic mini-open and open technique for thoracolumbar burst fractures with severe traumatic spinal stenosis.Journal of orthopaedic surgery and research · 2022Article
- Associations between Vitamin D, Omega 6:Omega 3 Ratio, and Biomarkers of Aging in Individuals Living with and without Chronic Pain.Nutrients · 2022Article
- 12 Weeks of Physical Exercise Attenuates Oxidative Stress, Improves Functional Tests Performance, and Reduces Fall Risk in Elderly Women Independently on Serum 25(OH)D Concentration.Frontiers in physiology · 2022Article
- The Proper Diet and Regular Physical Activity Slow Down the Development of Parkinson Disease.Aging and disease · 2021Review
- The Positive Impact of Vitamin D on Glucocorticoid-Dependent Skeletal Muscle Atrophy.Nutrients · 2021Article
- Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.Scientific reports · 2020Article
- The Relationship Between Serum 25[OH]D Concentration and Orthopaedic Infection: A Case-Control Study.Orthopedic research and reviews · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this experimental study was to assess whether 5 weeks of preoperative supplementation with vitamin D affects the intensity of pain and the level of inflammatory markers in patients undergoing posterior lumbar interbody fusion (PLIF) followed by rehabilitation. 42 patients were divided, by double-blind randomization, into two groups: supplemented (SUPL) vitamin D (3200 IU dose of vitamin D/day for 5 weeks) and placebo group (PL) treated with vegetable oil. The 10-week program of early rehabilitation (3 times a week) was initiated 4 weeks following PLIF. Measurements of serum 25(OH)D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.