ArticleFrontiers in neuroscience2019
Different Dopaminergic Dysfunctions Underlying Parkinsonian Akinesia and Tremor.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Neuroinflammation and noradrenergic modulation with β2-adrenoceptors: Emerging therapeutic targets for Parkinson's diseases.Neural regeneration research · 2026Article
- Association between nigrosome-1 appearance on MRI and fine motor function in healthy adults and people living with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- System-level hypothesis of dopamine imbalance in early multiple sclerosis.Frontiers in neurology · 2025Article
- Air Pollution and Parkinson Disease in a Population-Based Study.JAMA network open · 2024Article
- Simulating combined monoaminergic depletions in a PD animal model through a bio-constrained differential equations system.Frontiers in computational neuroscience · 2024Article
- In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.Cellular and molecular neurobiology · 2023Review
- The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease.IBRO neuroscience reports · 2022Review
- Development and validation of an instrument for measuring parkinsonian motor impairment: TRAPS-D.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- A dynamical model for the basal ganglia-thalamo-cortical oscillatory activity and its implications in Parkinson's disease.Cognitive neurodynamics · 2021Article
- Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders.International journal of molecular sciences · 2021Review
- A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection.The European journal of neuroscience · 2021Article
- Cortico-Cerebellar Hyper-Connections and Reduced Purkinje Cells Behind Abnormal Eyeblink Conditioning in a Computational Model of Autism Spectrum Disorder.Frontiers in systems neuroscience · 2021Article
- Increasing Serotonin to Reduce Parkinsonian Tremor.Frontiers in systems neuroscience · 2021Article
- Neurorobotic Models of Neurological Disorders: A Mini Review.Frontiers in neurorobotics · 2021Review
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3 authors.
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Abstract
Although the occurrence of Parkinsonian akinesia and tremor is traditionally associated to dopaminergic degeneration, the multifaceted neural processes that cause these impairments are not fully understood. As a consequence, current dopamine medications cannot be tailored to the specific dysfunctions of patients with the result that generic drug therapies produce different effects on akinesia and tremor. This article proposes a computational model focusing on the role of dopamine impairments in the occurrence of akinesia and resting tremor. The model has three key features, to date never integrated in a single computational system: (a) an architecture constrained on the basis of the relevant known system-level anatomy of the basal ganglia-thalamo-cortical loops; (b) spiking neurons with physiologically-constrained parameters; (c) a detailed simulation of the effects of both phasic and tonic dopamine release. The model exhibits a neural dynamics compatible with that recorded in the brain of primates and humans. Moreover, it suggests that akinesia might involve both tonic and phasic dopamine dysregulations whereas resting tremor might be primarily caused by impairments involving tonic dopamine release and the responsiveness of dopamine receptors. These results could lead to develop new therapies based on a system-level view of the Parkinson's disease and targeting phasic and tonic dopamine in differential ways.
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