Evidence map›Paper›PMID 31191213›Full record

ArticleFrontiers in neuroscience2019

A Novel Role of VEGFC in Cerebral Ischemia With Lung Injury.

Mu-Dong Wen, Ya Jiang, Jin Huang, Mohammed Al-Hawwas, Qi-Qin Dan, Rui-An Yang, Bing Yuan, Xiao-Ming Zhao, Ling Jiang, Ming-Mei Zhong and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Mu-Dong WenDepartment of Respiration, The First People's Hospital of Yunnan Province, Kunming, China.
Ya JiangLaboratory Zoology Department, Institute of Neuroscience, Kunming Medical University, Kunming, China.
Jin HuangLaboratory Zoology Department, Institute of Neuroscience, Kunming Medical University, Kunming, China.
Mohammed Al-HawwasSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia.
Qi-Qin DanInstitute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
Rui-An YangDepartment of Respiration, The First People's Hospital of Yunnan Province, Kunming, China.
Bing YuanDepartment of Respiration, The First People's Hospital of Yunnan Province, Kunming, China.
Xiao-Ming ZhaoInstitute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
Ling JiangInstitute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
Ming-Mei ZhongDepartment of Respiration, The First People's Hospital of Yunnan Province, Kunming, China.
Liu-Lin XiongDepartment of Anesthesiology, National Traditional Chinese Medicine Clinical Research Base and Western Medicine Translational Medicine Research Center, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Yun-Hui ZhangDepartment of Respiration, The First People's Hospital of Yunnan Province, Kunming, China.
First People's Hospital of Yunnan Province · CNKunming Medical University · CNSichuan University · CNSouthwest Medical University · CNUniversity of South Australia · AUWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia (CI) is a severe brain injury resulting in a variety of motor impairments combined with secondary injury in remote organs, especially the lung. This condition occurs due to insufficient blood supply to the brain during infancy. However, it has a molecular linkage that needs to be thoroughly covered. Here, we report on the role of vascular endothelial growth factor C (VEGFC) in lung injury induced by CI. The middle cerebral artery occlusion (MCAO) was depended to establish the animal model of CI. Rats were used and brain ischemia was confirmed through TTC staining. Serum was used for protein chip analysis to study the proteomic interaction. Immunohistochemistry analyses were used to quantify and locate the VEGFC in the lung and brain. The role of VEGFC was detected by siVEGFC technology in SY5Y, HUCEV, and A549 cell lines, under normal and oxygen glucose deprivation (OGD) conditions

Indexed as

cell culturecerebral ischemialung injuryprotein chip analysisVEGFC

Identifiers

PMID31191213
PMCPMC6540825
OpenAlexW2945010916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.