ReviewFrontiers in neuroscience2019
The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Organophosphate pesticides: a review on classification, synthesis, toxicity, remediation and analysis.RSC advances · 2025Review
- Enzyme-armed nanocleaner provides superior detoxification against organophosphorus compounds via a dual-action mechanism.Journal of nanobiotechnology · 2024Article
- In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells.Chemical research in toxicology · 2023Article
- Pharmacokinetics of three novel pyridinium aldoxime acetylcholinesterase reactivators in female rats.Toxicology and applied pharmacology · 2022Article
- Electrochemical detection of methyl-paraoxon based on bifunctional cerium oxide nanozyme with catalytic activity and signal amplification effect.Journal of pharmaceutical analysis · 2021Article
- Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach.Scientific reports · 2021Article
- Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl.International journal of molecular sciences · 2021Article
- Understanding the Interaction Modes and Reactivity of Trimedoxime towardInternational journal of molecular sciences · 2020Article
- Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats.Molecules (Basel, Switzerland) · 2020Article
- Combined Pre- and Posttreatment of Paraoxon Exposure.Molecules (Basel, Switzerland) · 2020Article
- Recent developments on oximes to improve the blood brain barrier penetration for the treatment of organophosphorus poisoning: a review.RSC advances · 2020Review
- Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory. In search of more efficacious broad-spectrum oximes, new bispyridinium (K-) oximes have been synthesized, with K027 being among the most promising. This review summarizes pharmacokinetic characteristics of K027, its toxicity and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.