Evidence map›Paper›PMID 31191070›Full record

ReviewClinical medicine insights. Reproductive health2019

Female Fertility Preservation through Stem Cell-based Ovarian Tissue Reconstitution In Vitro and Ovarian Regeneration In Vivo.

Taichi Akahori, Dori C Woods, Jonathan L Tilly

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical medicine insights. Reproductive health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Advances inFrontiers in endocrinology · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. A Journey to Reach the Ovary Using Next-Generation Technologies.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Taichi AkahoriLaboratory for Aging and Infertility Research, Department of Biology, Northeastern University, Boston, MA, USA.
Dori C WoodsLaboratory for Aging and Infertility Research, Department of Biology, Northeastern University, Boston, MA, USA.
Jonathan L TillyLaboratory for Aging and Infertility Research, Department of Biology, Northeastern University, Boston, MA, USA.
Northeastern University · US

Funding

Origins and Functions of Mammalian Female Germline Stem CellsR01AG012279 · NIA · NORTHEASTERN UNIVERSITY · PI TILLY, JONATHAN LEE · 1995 to 2021
$2.7M
Lineage tracing of germline stem cell differentiation in adult ovariesR21HD072280 · NICHD · NORTHEASTERN UNIVERSITY · PI TILLY, JONATHAN LEE, WANG, NING · 2012 to 2013
$422k
NIA NIH HHS R01 AG012279NICHD NIH HHS R21 HD072280
6 · The paper itself

Abstract

Historically, approaches designed to offer women diagnosed with cancer the prospects of having a genetically matched child after completion of their cytotoxic treatments focused on the existing oocyte population as the sole resource available for clinical management of infertility. In this regard, elective oocyte and embryo cryopreservation, as well as autologous ovarian cortical tissue grafting posttreatment, have gained widespread support as options for young girls and reproductive-age women who are faced with cancer to consider. In addition, the use of ovarian protective therapies, including gonadotropin-releasing hormone agonists and sphingosine-1-phosphate analogs, has been put forth as an alternative way to preserve fertility by shielding existing oocytes in the ovaries in vivo from the side-effect damage caused by radiotherapy and many chemotherapeutic regimens. This viewpoint changed with the publication of now numerous reports that adult ovaries of many mammalian species, including humans, contain a rare population of oocyte-producing germ cells-referred to as female germline or oogonial stem cells (OSCs). This new line of study has fueled research into the prospects of generating new oocytes, rather than working with existing oocytes, as a novel approach to sustain or restore fertility in female cancer survivors. Here, we overview the history of work from laboratories around the world focused on improving our understanding of the biology of OSCs and how these cells may be used to reconstitute "artificial" ovarian tissue in vitro or to regenerate damaged ovarian tissue in vivo as future fertility-preservation options.

Indexed as

chemotherapyfertilityfolliculogenesisoocyteoogenesisovarystem cell

Identifiers

PMID31191070
PMCPMC6540489
OpenAlexW2946642143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.