ArticleNeuropsychiatric disease and treatment2019
Structural changes in white matter lesion patients and their correlation with cognitive impairment.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial.JAMA network open · 2023Trial
- Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment.Frontiers in aging neuroscience · 2026Article
- Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease.Neuroradiology · 2025Article
- Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients.Scientific reports · 2024Article
- Comparing the Efficacy of Two Cognitive Screening Tools in Identifying Gray and White Matter Brain Damage among Older Adults.Journal of aging research · 2024Article
- Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity.Aging and disease · 2023Article
- White matter microstructure changes in adults with major depressive disorder: evidence from diffusion magnetic resonance imaging.BJPsych open · 2023Article
- Differences in Gray Matter Volume in Cerebral Small Vessel Disease Patients with and without Sleep Disturbance.Brain sciences · 2023Article
- Predicting the severity of white matter lesions among patients with cerebrovascular risk factors based on retinal images and clinical laboratory data: a deep learning study.Frontiers in neurology · 2023Article
- Study of gray matter atrophy pattern with subcortical ischemic vascular disease-vascular cognitive impairment no dementia based on structural magnetic resonance imaging.Frontiers in aging neuroscience · 2023Article
- Evaluating white matter alterations in Parkinson's disease-relatedQuantitative imaging in medicine and surgery · 2022Article
- Topologic Efficiency Abnormalities of the Connectome in Asymptomatic Patients with Leukoaraiosis.Brain sciences · 2022Article
- Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease.BMC medical imaging · 2022Article
- Individual prediction and classification of cognitive impairment in patients with white matter lesions based on gray matter volume.Annals of translational medicine · 2022Article
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
- Lacunar infarction aggravates the cognitive deficit in the elderly with white matter lesion.Open life sciences · 2022Article
- Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment.Neuroscience bulletin · 2021Article
- Role of Preoperative Assessment in Predicting Tumor-Induced Plasticity in Patients with Diffuse Gliomas.Journal of clinical medicine · 2021Article
- Abnormal Cerebral Blood Flow and Functional Connectivity Strength in Subjects With White Matter Hyperintensities.Frontiers in neurology · 2021Article
- The potential role of leukoaraiosis in remodeling the brain network to buffer cognitive decline: a Leukoaraiosis And Disability study from Alzheimer's Disease Neuroimaging Initiative.Quantitative imaging in medicine and surgery · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhite matter lesions (WMLs) play a role in cognitive decline and dementia. Little is known about gray matter (GM) changes in WMLs. This study aimed to investigate GM changes in WML patients. MATERIALS AND
methodsCorrelations between altered structural volume and cognitive assessment scores were investigated. GM and white matter (WM) changes in 23 WML-vascular dementia (VaD) patients, 22 WML-non-dementia vascular cognitive impairment (VCIND) patients, and 23 healthy control (HC) subjects were examined. Gray matter density (GMD) was calculated by measuring local proportions of GM at thousands of homologous cortical locations. WM volume was obtained by fully automated software using voxel-based morphometry (VBM).
resultsWidespread GMD was significantly lower in WML patients compared to control subjects in cortical and subcortical regions (
conclusionGMD and WM volume were changed in WMLs, and the changes were detectable. Correlation between structural changes and cognitive function was promising in understanding the pathological and physiological mechanisms of WMLs.
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