Evidence map›Paper›PMID 31190738›Full record

ArticleDrug design, development and therapy2019

Extending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells.

M Ramezani Farani, P Khadive Parsi, Gh Riazi, M Shafiee Ardestani, H Saligeh Rad

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Article in Drug design, development and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M Ramezani FaraniSchool of Chemical Engineering, University College of Engineering, University of Tehran, Tehran 4563-11155, Iran, kparsi@ut.ac.ir.
P Khadive ParsiSchool of Chemical Engineering, University College of Engineering, University of Tehran, Tehran 4563-11155, Iran, kparsi@ut.ac.ir.
Gh RiaziInstitute of Biophysics and Biochemistry, University of Tehran, Tehran 1417614411, Iran.
M Shafiee ArdestaniDepartment of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran, shafieeardestani@sina.tums.ac.ir.
H Saligeh RadQuantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn this study, novel graphene oxide (GO)-based nanocomposites are presented. In fact, we have tried to replace the carboxyl groups on the surface of GO with amine groups to allow the biocompatible poly(ethylene glycol) bis(carboxymethyl) ether (average Mn 600) polymer to bond through an amide bond. MATERIALS AND

methodsThe synthesis was conducted accurately according to final characterization experiments (Raman, X-ray diffraction [XRD], atomic force microscopy [AFM], X-ray photoelectron spectroscopy [XPS], thermogravimetric analysis [TGA], etc). The antimicrobial property of this nanocomposite was examined in

resultsAn intense increase in toxicity was detected by MTT assay.

conclusionIt can mainly be concluded that the nanocomposite synthesized in this study is capable of delivering drugs with antibacterial properties.

Indexed as

AnimalsAnti-Bacterial AgentsAntineoplastic AgentsCell ProliferationCell SurvivalDrug LiberationDrug Screening Assays, AntitumorGram-Negative BacteriaGram-Positive BacteriaGraphiteHep G2 CellsHumansMagnetite NanoparticlesMicrobial Sensitivity TestsMolecular StructureNeoplasmsAnti-Bacterial AgentsAntineoplastic Agentsgraphene oxideGraphiteMagnetite NanoparticlesPolyethylene Glycolsantimicrobialcurcumindrug deliverygraphene oxidemagnetic nanocomposite

Identifiers

PMID31190738
PMCPMC6512786

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.