Evidence map›Paper›PMID 31190460›Full record

ArticleJournal of the International AIDS Society2019

Improvements in the South African HIV care cascade: findings on 90-90-90 targets from successive population-representative surveys in North West Province.

Sheri A Lippman, Alison M El Ayadi, Jessica S Grignon, Adrian Puren, Teri Liegler, W D Francois Venter, Mary J Ratlhagana, Jessica L Morris, Evasen Naidoo, Emily Agnew and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International AIDS Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  20. Built Environment and HIV Linkage to Care in Rural South Africa.Community health equity research & policy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sheri A LippmanCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0003-3152-9372
Alison M El AyadiBixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Jessica S GrignonDepartment of Global Health, University of Washington, Seattle, WA, USA.
Adrian PurenCentre for HIV and STIs, National Institute for Communicable Diseases/NHLS, Division of Virology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Teri LieglerHIV/AIDS Division, Department of Medicine, HIV, Infectious Diseases and Global Health Division, University of California, San Francisco, CA, USA.
W D Francois VenterWits Reproductive Health and HIV Institute (WRHI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mary J RatlhaganaInternational Training and Education Center for Health (I-TECH) South Africa, Pretoria, Republic of South Africa.
Jessica L MorrisCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, CA, USA.
Evasen NaidooInternational Training and Education Center for Health (I-TECH) South Africa, Pretoria, Republic of South Africa.
Emily AgnewCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, CA, USA.
Scott BarnhartDepartment of Global Health, University of Washington, Seattle, WA, USA.
Starley B ShadeCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of the Witwatersrand · ZAUniversity of Washington · USIbis Reproductive Health · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Comprehensive Reintegration Assistance for Women with Obstetric FistulaK99HD086232 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EL AYADI, ALISON M · 2016 to 2017
$316k
CGH CDC HHS U2G GH000324NIAID NIH HHS P30 AI027763NICHD NIH HHS K99 HD086232NIMH NIH HHS P30 MH062246PEPFAR
6 · The paper itself

Abstract

introductionTo achieve epidemic control of HIV by 2030, countries aim to meet 90-90-90 targets to increase knowledge of HIV-positive status, initiation of antiretroviral therapy (ART) and viral suppression by 2020. We assessed the progress towards these targets from 2014 to 2016 in South Africa as expanded treatment policies were introduced using population-representative surveys.

methodsData were collected in January to March 2014 and August to November 2016 in Dr. Ruth Segomotsi Mompati District, North West Province. Each multi-stage cluster sample included 46 enumeration areas (EA), a target of 36 dwelling units (DU) per EA, and a single resident aged 18 to 49 per DU. Data collection included behavioural surveys, rapid HIV antibody testing and dried blood spot collection. We used weighted general linear regression to evaluate differences in the HIV care continuum over time.

resultsOverall, 1044 and 971 participants enrolled in 2014 and 2016 respectively with approximately 77% undergoing HIV testing. Despite increases in reported testing, known status among people living with HIV (PLHIV) remained similar at 68.7% (95% Confidence Interval (CI) = 60.9-75.6) in 2014 and 72.8% (95% CI = 63.6-80.4) in 2016. Men were consistently less likely than women to know their status. Among those with known status, PLHIV on ART increased significantly from 80.9% (95% CI = 71.9-87.4) to 91.5% (95% CI = 84.4-95.5). Viral suppression (<5000 copies/mL using DBS) among those on ART increased significantly from 55.0% (95% CI = 39.6-70.4) in 2014 to 81.4% (95% CI = 72.0-90.8) in 2016. Among all PLHIV an estimated 72.0% (95% CI = 63.8-80.1) of women and 45.8% (95% CI = 27.0-64.7) of men achieved viral suppression by 2016.

conclusionsOver a period during which fixed-dose combination was introduced, ART eligibility expanded, and efforts to streamline treatment were implemented, major improvements in the second and third 90-90-90 targets were achieved. Achieving the first 90 target will require targeted and improved testing models for men.

Indexed as

AdolescentAdultAnti-HIV AgentsContinuity of Patient CareEpidemicsFemaleHIVHIV InfectionsHumansMaleMass ScreeningMiddle AgedSouth AfricaYoung AdultAnti-HIV Agents90-90-90 targetscare cascadeHIVHIV care continuumlinkage to careSouth Africatestingviral suppression

Identifiers

PMID31190460
PMCPMC6562149
OpenAlexW2952680342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.