ArticleAMB Express2019
Evaluation of surfactin synthesis in a genome reduced Bacillus subtilis strain.
Article in AMB Express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The Surfactin-Like Lipopeptides FromFrontiers in bioengineering and biotechnology · 2021Pooled it
- Biotechnological Potential of RhizosphericInternational journal of molecular sciences · 2026Article
- Making GFP count: a validated framework for absolute protein quantification in precision fermentation.Applied microbiology and biotechnology · 2026Article
- Advances and challenges in the integration of artificial intelligence in microbial biosurfactant bioprocess.AMB Express · 2025Review
- Recombinant Production of Bovine αMicroorganisms · 2025Article
- Application of Combined Irradiation Mutagenesis Technique for Hyperproduction of Surfactin inInternational journal of microbiology · 2025Article
- The influence of growth rate-controlling feeding strategy on the surfactin production in Bacillus subtilis bioreactor processes.Microbial cell factories · 2024Article
- Metabolic Profile of the Genome-ReducedACS synthetic biology · 2024Article
- Research advances in the identification of regulatory mechanisms of surfactin production by Bacillus: a review.Microbial cell factories · 2024Review
- Structural Diversity of the Lipopeptide Biosurfactant Produced by a Newly Isolated Strain,ACS omega · 2023Article
- Deletion of Rap-phosphatases for quorum sensing control in Bacillus and its effect on surfactin production.AMB Express · 2023Article
- Article
- Characterization ofantifungal properties of lipopeptide-producingFrontiers in bioengineering and biotechnology · 2023Article
- Evaluation of an external foam column forFrontiers in bioengineering and biotechnology · 2023Article
- Surfactin Shows Relatively Low Antimicrobial Activity againstMicroorganisms · 2022Article
- Modeling the time course of ComX: towards molecular process control for Bacillus wild-type cultivations.AMB Express · 2021Article
- Expression of degQ gene and its effect on lipopeptide production as well as formation of secretory proteases in Bacillus subtilis strains.MicrobiologyOpen · 2021Article
- Influence of B. subtilis 3NA mutations in spo0A and abrB on surfactin production in B. subtilis 168.Microbial cell factories · 2021Article
- Bacillus subtilis High Cell Density Fermentation Using a Sporulation-Deficient Strain for the Production of Surfactin.Applied microbiology and biotechnology · 2021Article
- Evaluation of an oxygen-dependent self-inducible surfactin synthesis in B. subtilis by substitution of native promoter PAMB Express · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Strain engineering is often a method of choice towards increasing the yields of the biosurfactant surfactin which is naturally synthesized by many Bacillus spp., most notably Bacillus subtilis. In the current study, a genome reduced B. subtilis 168 strain lacking 10% of the genome was established and tested for its suitability to synthesize surfactin under aerobic and anaerobic conditions at 25 °C, 30 °C, 37 °C and 40 °C. This genome reduced strain was named IIG-Bs20-5-1 and lacks, amongst others, genes synthesizing the lipopeptide plipastatin, the antibiotic bacilysin, toxins and prophages, as well as genes involved in sporulation. Amongst all temperatures tested, 37 °C was overall superior. In comparison to the reference strain JABs24, a surfactin synthesizing variant of B. subtilis 168, strain IIG-Bs20-5-1 was both aerobically and anaerobically superior with respect to specific growth rates µ and yields Y
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.