Evidence map›Paper›PMID 31190299›Full record

ArticleInfection2019

Impact of refugee influx on the epidemiology of late-presenting HIV-infected pregnant women and mother-to-child transmission: comparing a southern and northern medical centre in Germany.

Katharina Singer, Ulf Schulze-Sturm, Irene Alba-Alejandre, Bettina Hollwitz, Thi Thanh Truc Nguyen, Franz Sollinger, Josef Eberle, Johannes Hübner, Robin Kobbe, Orsolya Genzel-Boroviczény and 1 more

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In one paragraph

Article in Infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katharina Singer *Division of Neonatology Campus Innenstadt, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Ulf Schulze-Sturm *Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Irene Alba-AlejandreDepartment of Obstetrics and Gynaecology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Bettina HollwitzDepartment of Obstetrics and Prenatal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thi Thanh Truc NguyenDepartment of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Franz SollingerDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Josef EberleDivision of Virology, National Reference Center for Retroviruses, Max von Pettenkofer-Institute for Hygiene and Clinical Microbiology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Johannes HübnerDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Robin KobbeDepartment of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Orsolya Genzel-BoroviczényDivision of Neonatology Campus Innenstadt, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Ulrich von BothDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. ulrich.von.both@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-8411-1071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDue to early antenatal screening and treatment, HIV mother-to-child transmission (MTCT) rarely occurs in Germany. The study aimed to investigate the impact on prevalence of HIV infection in the antenatal population and the incidence of late-presenting HIV-infected mothers attributable to increased numbers of refugees.

methodsRetrospective analysis and comparison were performed for all deliveries in HIV-infected pregnant women presenting to medical care in Munich (southern Germany) and Hamburg (northern Germany) covering two time periods, A (2010-2012) and B (2013-2015).

resultsIn Munich, deliveries in HIV-infected pregnant women increased 1.6-fold from period A (n = 50) to B (n = 79) with late-presenting cases rising significantly from 2% (1/50) in period A to 13% (10/79) in B. In contrast, late-presenting cases in Hamburg decreased from 14% (14/100) in period A to 7% (7/107) in B, while the total number of HIV-infected women giving birth remained stable. From 2010 to 2015, one late-presenting pregnant woman transmitted HIV in Munich by presumed in utero mode of infection (case reviewed here), while no MTCT occurred in Hamburg.

conclusionsHIV infections diagnosed late in pregnancy and leading to delayed ART initiation are rising in Munich compared to Hamburg. Antenatal care of HIV-infected pregnant women in Munich appears to have been more affected by the recent refugee influx than Hamburg. Our study highlights the importance of screening all pregnant women for HIV early in pregnancy and providing timely health care access for pregnant refugees and asylum seekers to effectively prevent MTCT in Germany.

Indexed as

RefugeesAdultAnti-HIV AgentsFemaleGeographyGermanyHealth Services AccessibilityHIV-1HIV InfectionsHumansInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousPrevalenceRetrospective StudiesTime-to-TreatmentAnti-HIV AgentsHIVLate presentingMother-to-child transmissionMTCTRefugees

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.