ArticleTechniques in coloproctology2019
The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database.
Article in Techniques in coloproctology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Differences in the expression of CMTM3 and SSTR2 genes in right and left colon tumors: A molecular insight into colorectal cancer.Medical oncology (Northwood, London, England) · 2025Article
- A Methodological and Survival Comparison of NCDB and SEER Database for Colon Cancer Research.Journal of surgical oncology · 2025Article
- Chronic Inflammation Index-Based Tumor Subsite Classification Correlated with Chemotherapy Benefit and Survival Outcomes in Stage II-III Colorectal Cancer.Journal of inflammation research · 2025Article
- Unraveling the role of tumor sidedness in prognosis of stage II colon cancer.Gastroenterology report · 2024Article
- Outcomes of right-sided and left-sided colon cancer after curative resection.Scientific reports · 2022Article
- Intratumoral density of regulatory T cells is a predictor of host immune response and chemotherapy response in colorectal cancer.American journal of cancer research · 2022Article
- MicroRNA-323a-3p Negatively Regulates NEK6 in Colon Adenocarcinoma Cells.Journal of oncology · 2022Article
- Development and validation of a new stage-specific nomogram model for predicting cancer-specific survival in patients in different stages of colon cancer: A SEER population-based study and external validation.Frontiers in oncology · 2022Article
- The primary tumor location in colorectal cancer: A focused review on its impact on surgical management.Global health & medicine · 2021Review
- Article
- Association of day of the week with mortality after elective right hemicolectomy for colon cancer: Case analysis from the National Clinical Database.Annals of gastroenterological surgery · 2021Article
- Right sided colorectal cancer increases with age and screening should be tailored to reflect this: a national cancer database study.Techniques in coloproctology · 2021Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to conflicting study results on the effect of laterality on overall survival in primary colon cancers, we sought to examine the impact of left compared to right-sided primary tumors on overall survival for stage I-III colon cancer using the largest dataset to date.
methodsThe 2006-2013 NCDB was queried for patients with single primary, stage I-III colon adenocarcinoma and grouped by stage and tumor location.
resultsFor stage I-II tumors, 114,839 patients had resection (62% right:38% left). After adjustment, patients with right-sided tumors had superior survival ([HR right as reference]: 1.13, 95% CI 1.09-1.17, p < 0.001). For stage III tumors, 71,024 patients had resection, (59% right:41% left). After adjustment, patients with left-sided tumors had superior survival with chemotherapy (HR 0.85, p < 0.001) and no difference in survival without chemotherapy (HR 0.97, p = 0.18).
conclusionsThe side of the primary tumor impacts overall survival across stages for colon adenocarcinoma. Patients with right-sided tumors have superior survival for stage I-II disease while patients with left-sided stage III disease demonstrate a survival advantage, suggesting an opportunity for investigators to use sidedness as a surrogate for prognosis and chemoresponsiveness.
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