Evidence map›Paper›PMID 31190152›Full record

ArticleWorld journal of urology2020

Long-term oncologic outcomes of robot-assisted radical cystectomy (RARC) with totally intracorporeal urinary diversion (ICUD): a multi-center study.

Aldo Brassetti, Giovanni Cacciamani, Umberto Anceschi, Mariaconsiglia Ferriero, Gabriele Tuderti, Gus Miranda, Riccardo Mastroianni, Mihir Desai, Monish Aron, Inderbir Gill and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. Health-related quality of life after radical cystectomy.Translational andrology and urology · 2020
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  20. Robotic surgery in urology: the way forward.World journal of urology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aldo BrassettiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy. aldo.brassetti@gmail.com.ORCID http://orcid.org/0000-0001-9643-8979
Giovanni CacciamaniDepartment of Urology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8892-5539
Umberto AnceschiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Mariaconsiglia FerrieroDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Gabriele TudertiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Gus MirandaDepartment of Urology, University of Southern California, Los Angeles, CA, USA.
Riccardo MastroianniDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Mihir DesaiDepartment of Urology, University of Southern California, Los Angeles, CA, USA.
Monish AronDepartment of Urology, University of Southern California, Los Angeles, CA, USA.
Inderbir GillDepartment of Urology, University of Southern California, Los Angeles, CA, USA.
Michele GallucciDepartment of Urology, "Sapienza" University of Rome, Rome, Italy.
Giuseppe SimoneDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.ORCID http://orcid.org/0000-0002-4868-9025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report survival outcomes after robot-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) for recurrent/muscle-invasive non-metastatic bladder cancer.

methodsProspectively maintained databases were queried for "robotic cystectomy AND ICUD". Patients treated after October 2013 and those treated without curative intent were excluded. Kaplan-Meier method was used to plot stage-specific survival outcomes, computed at 1, 2, and 5 years after surgery. Univariable and multivariable Cox analyses assessed predictors of recurrence-free (RFS), cancer-specific (CSS) and overall (OS) survival.

results113 consecutive patients were included, mostly men (82%). Neoadjuvant chemotherapy was performed in 23% of cases, median lymph node (LN) yield was 36 (IQR 28-45) and the rate of positive surgical margins (PSM) was 8%. Orthotopic ileal neobladder was the preferred ICUD type (57%). An organ-confined disease was observed in 51% of cases and 21% were pT0 on final histology. Overall, 5-year RFS, CSS and OS probabilities were 58 ± 5%, 61 ± 5% and 54 ± 5%, respectively. At Kaplan-Meier method, tumor stage group was a significant predictor of survival probabilities (all p < 0.001) and this was confirmed at multivariable Cox regression analysis (RFS-OR 2.29; 95% CI 1.58-3.32; p < 0.001) (CSS-OR 1.82; 95% CI 1.3-2.53; p < 0.001) (OS-OR 2.14; 95% CI 1.46-3.14; p < 0.001). PSM status was associated to CSS (OR 2.54; 95% CI 1.13-5.69; p = 0.024) and OS (OR 2.82; 95% CI 1.17-6.77; p = 0.021), but did not predict RFS (p = 0.062).

conclusionsLong-term oncologic outcomes after RARC with ICUD appear similar to recent robotic series with extracorporeal diversion and historical open experiences.

Indexed as

Robotic Surgical ProceduresAgedCystectomyFemaleHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalRetrospective StudiesTime FactorsTreatment OutcomeUrinary Bladder NeoplasmsUrinary DiversionBladder cancerLong-term outcomesRadical cystectomyRoboticSurvivalUrothelial carcinoma

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.