Association between adherence to antihypertensive medications and health outcomes in middle and older aged community dwelling adults; results from the Irish longitudinal study on ageing.

Caroline A Walsh, Caitriona Cahir, Kathleen E Bennett

Abstract read

In one paragraph

Article in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed, 2 pooled it

1.0field-weighted citation impact, top 24% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta-Analysis Involving 27 Million Patients.Journal of the American Heart Association · 2022
Pooled it
Sex differences in the adherence of antihypertensive drugs: a systematic review with meta-analyses.BMJ open · 2020
Pooled it
Goal attainment, medication adherence and guideline adherence in the treatment of hypertension and dyslipidemia in Irish populations: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Caroline A WalshDivision of Population Health Sciences, Beaux Lane House, Royal College of Surgeons in Ireland, Lower Mercer Street, Dublin 2, Ireland. carolinewalsh@rcsi.com.ORCID http://orcid.org/0000-0001-9749-5916

Caitriona CahirDivision of Population Health Sciences, Beaux Lane House, Royal College of Surgeons in Ireland, Lower Mercer Street, Dublin 2, Ireland.

Kathleen E BennettDivision of Population Health Sciences, Beaux Lane House, Royal College of Surgeons in Ireland, Lower Mercer Street, Dublin 2, Ireland.

Royal College of Surgeons in Ireland · IE

Funding

Health Research Board HRB RL-2015-1579

6 · The paper itself

Abstract

purposeTo examine the association between antihypertensive medication (AHTM) implementation adherence and healthcare utilisation in community-dwelling adults aged ≥ 50 years in Ireland.

methodsThis was a prospective cohort study. The Irish Longitudinal Study on Ageing (TILDA) was linked to pharmacy claims data for participants aged ≥ 50 years. Participants were included if they had ≥ 3 pharmacy claims for one or more AHTM (ATC codes 'C02', 'C03', 'C07', 'C08' or 'C09') within the year preceding the year of self-reported healthcare utilisation outcome occurrence. Outcomes included self-reported general practitioner (GP), emergency department (ED), outpatient department visits and hospital admissions. Implementation adherence was measured using proportion of days covered (PDC), with participants classified as adherent if the average PDC ≥ 0.8. Negative binomial models were used to analyse the association between AHTM adherence and number of GP, ED, outpatient visits and hospitalisations (adjusted IRR and 95% CI are presented).

resultsOne thousand four hundred thirty-one participants were included. The majority of participants (72.6%) were considered adherent. Good implementation adherence to AHTM was associated with a significant decrease in self-reported GP visits (adjusted IRR 0.91, 95% CI 0.83-0.99). Adherence had no significant impact on the number of ED visits, outpatient visits or hospitalisations reported by TILDA participants.

conclusionsGood adherence to AHTM was associated with less self-reported GP visits in this population, suggesting improved overall health status. However, the impact of medication non-adherence on the other self-reported healthcare utilisation outcomes (ED, outpatient visits and hospitalisations) was not evident in this study.

Indexed as

Drug MonitoringAgedAmbulatory CareAntihypertensive AgentsEmergency Service, HospitalFemaleHealth StatusHospitalizationHumansHypertensionIndependent LivingIrelandMaleMiddle AgedProspective StudiesAntihypertensive AgentsHealth outcomesHospitalisationMedication adherenceOlder

Identifiers

PMID31190134

DOI10.1007/s00228-019-02699-w

OpenAlexW2952296247

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.